Chlorzoxazone-d3
(Synonyms: 氯唑沙宗 d3) 目录号 : GC49191
An internal standard for the quantification of chlorzoxazone
Cas No.:1185173-60-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chlorzoxazone-d3 is intended for use as an internal standard for the quantification of chlorzoxazone by GC- or LC-MS. Chlorzoxazone is a centrally acting muscle relaxant and an activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively).1,2 In vivo, chlorzoxazone (10 mg/kg) decreases alcohol, but not water, intake in a dose-dependent manner and reduces the propensity for rapid initial alcohol intake in rats with intermittent, but not continuous, access to alcohol.3 Formulations containing chlorzoxazone have been used in the treatment of pain and stiffness caused by muscle spasm.
1.Pedarzani, P., and Stocker, M.Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brainCell. Mol. Life Sci.65(20)3196-3217(2008) 2.Gao, Z., Todorov, B., Barrett, C.F., et al.Cerebellar ataxia by enhanced Cav2.1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1aS218L mutant miceJ. Neurosci.32(44)15533-15546(2012) 3.Hopf, F.W., Simms, J.A., Chang, S.-J., et al.Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in ratsBiol. Psychiatry69(7)618-624(2011)
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 5.7937 mL | 28.9687 mL | 57.9374 mL |
| 5 mM | 1.1587 mL | 5.7937 mL | 11.5875 mL |
| 10 mM | 0.5794 mL | 2.8969 mL | 5.7937 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。