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Chondroitin Sulfate A (sodium salt)

(Synonyms: Chondroitin-4-sulfate,CSA) 目录号 : GC91489

Chondroitin sulfate A (CSA) is a glycosaminoglycan.

Chondroitin Sulfate A (sodium salt) Chemical Structure

Cas No.: 9082-07-9

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5 g
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50 g
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产品描述

Chondroitin sulfate A (CSA) is a glycosaminoglycan.[1] It can be biosynthetically polymerized in a variety of species and serve as structural components in cartilage when tethered to extracellular proteins. CSA (0.5 or 1 mg/ml) reduces LPS-induced decreases in viability, as well as LPS-induced increases in Tnf-α, Il-1β, Il-6, Ifn-γ, inducible nitric oxide synthase (iNOS), and matrix metalloproteinase-1 (Mmp-1) levels, nitric oxide (NO) production, and NF-κB activity in primary mouse chondrocytes.[2] Extracellular CSA is required for P. falciparum-infected erythrocytes to adhere to the endothelium in the brain and placenta and avoid immune detection.[3] In vivo, CSA (30, 60, or 120 mg/kg per day) reduces arthritis incidence and joint swelling, decreases 8-isoprostane levels in articular cartilage cells, and increases IκBα levels in cartilage cell cytoplasm in a mouse model of collagen-induced arthritis.[4]

References:
[1].Kwok, J.C.F., Warren, P., and Fawcett, J.W.Chondroitin sulfate: A key molecule in the brain matrixInt. J. Biochem. Cell Biol.44(4)582-586(2012).
[2].Campo, G.M., Avenoso, A., Campo, S., et al.Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytesJ. Cell. Biochem.106(1)83-92(2009).
[3].Reeder, J.C., Cowman, A.F., Davern, K.M., et al.The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1Proc. Natl. Acad. Sci. U.S.A.96(9)5198-5120(1999).
[4].Campo, G.M., Avenoso, A., Campo, S., et al.Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in miceOsteoarthritis Cartilage16(12)1474-1483().

Chemical Properties

Cas No. 9082-07-9 SDF Download SDF
别名 Chondroitin-4-sulfate,CSA
分子式 C14H22NO15S•Na 分子量 499.4
溶解度 PBS (pH 7.2): 2 mg/ml 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mM 2.0024 mL 10.012 mL 20.024 mL
5 mM 0.4005 mL 2.0024 mL 4.0048 mL
10 mM 0.2002 mL 1.0012 mL 2.0024 mL
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