Chromafenozide (ANS118)
(Synonyms: 环虫酰肼; ANS118) 目录号 : GC33554
Chromafenozide (ANS118) (ANS118) 是一种鳞翅目杀虫剂；对防治各种鳞翅目害虫效果显着。
Cas No.:143807-66-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chromafenozide (ANS118) is a lepidopteran insecticide; it is highly effective in controlling various lepidopteran pests.
| Cas No. | 143807-66-3 | SDF | |
| 别名 | 环虫酰肼; ANS118 | ||
| Canonical SMILES | O=C(C1=CC=C2C(CCCO2)=C1C)NN(C(C3=CC(C)=CC(C)=C3)=O)C(C)(C)C | ||
| 分子式 | C24H30N2O3 | 分子量 | 394.51 |
| 溶解度 | DMSO: 250 mg/mL (633.70 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5348 mL | 12.6739 mL | 25.3479 mL |
| 5 mM | 0.507 mL | 2.5348 mL | 5.0696 mL |
| 10 mM | 0.2535 mL | 1.2674 mL | 2.5348 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Safety assessment of Chromafenozide residue level with decline study on tomato in Egypt
Environ Monit Assess 2017 Apr;189(4):180.PMID:28342049DOI:10.1007/s10661-017-5894-6.
The objective of this study is to perform a safety assessment of Chromafenozide residue level on tomato at the Egyptian national level. An open field decline study of Chromafenozide on tomato was performed. The theoretical maximum daily intake (TMDI) of Chromafenozide was calculated for assessing the chronic dietary exposure indicating that the ADI value of Chromafenozide (0.27 mg/kg bw/day) was not exceeded. As a result, the safety assessment of Chromafenozide residue levels was attained. A validated method of the QuEChERS approach followed by HPLC-DAD analysis was used to determine the Chromafenozide residues. The recoveries ranged from 70 to 88% with relative standard deviations ranging from 2.0 to 9.0%. The limit of quantitation was 0.01 mg/kg. The half-life of Chromafenozide on tomatoes was 3.5 days.
Residues, dissipation and safety evaluation of Chromafenozide in strawberry under open field conditions
Food Chem 2014;152:18-22.PMID:24444901DOI:10.1016/j.foodchem.2013.11.110.
The dissipation and residual levels of new generation insecticide Chromafenozide in strawberries under field conditions were studied using HPLC-DAD after QuEChERS extraction. The method was validated using blank samples spiked at three levels and the results showed that recoveries ranged from 99% to 110%. The intra- and inter-day relative standard deviations were less than 7.5% and 9.2%, respectively. Estimated limit of detection and limit of quantification for Chromafenozide were 0.003 and 0.01 mg/kg, respectively. The residues of Chromafenozide were found to dissipate following first order kinetics and its half-life ranged from 3.53 to 4.07 days. The results showed that the use of Chromafenozide at recommended dose does not pose any hazards to consumers. These results can be utilised in formulating spray schedules and safety evaluation for Chromafenozide insecticide in strawberry.
Residual characteristics and safety assessment of the insecticides spiromesifen and Chromafenozide in lettuce and perilla
Sci Rep 2022 Mar 18;12(1):4675.PMID:35304538DOI:10.1038/s41598-022-08532-2.
This study was performed to investigate the residual characteristics, safety assessment, and pre-harvest interval (PHI) of spiromesifen and Chromafenozide in lettuce (Latuca sativa L.) and perilla (Perilla frutescens (L.) Britton) leaves. Samples were harvested periodically, extracted using QuEChERS method, and analyzed by LC-MS/MS. Average recoveries of spiromesifen and its metabolite BSN2060-enol and Chromafenozide were ranged from 80.6 to 107.9%, with relative standard deviation < 10%. Spiromesifen and cromafenozide initial residues in lettuce were dissipated to 81.45 and 95.52% after 7 days, with half-lives of 2.89 and 1.69 days respectively. Values in perilla leaves were 76.68 and 61.27% after the same period, with half-lives of 4.25 and 6.30 days, respectively. Risk assessment results showed that %ADI (acceptable daily intake) of spiromesifen and Chromafenozide was 6.83 and 0.56, in lettuce and 4.60 and 0.25% in perilla leaves, respectively. Theoretical maximum daily intakes of spiromesifen and Chromafenozide were 67.49 and 3.43%, respectively, indicating that residues of both compounds pose no considerable health risks to consumers. This study provides data for setting maximum residue limits and PHIs for the safe use of spiromesifen and Chromafenozide in lettuce and perilla.
HPLC method development and validation of Chromafenozide in paddy
Bull Environ Contam Toxicol 2012 Dec;89(6):1277-83.PMID:23052574DOI:10.1007/s00128-012-0822-5.
A simple and efficient HPLC-UV method was developed and validated for determination of Chromafenozide in paddy as there was no previous report on record in this regard. The residue analysis method of Chromafenozide, its dissipation and final residue in paddy along with soil were also studied after field treatment. Residues of Chromafenozide were extracted and purified from paddy and soil followed by liquid/liquid partitioning, chromatographic column and determination by HPLC equipped with PDA detector. The separation was performed on a Phenomenex Luna RP C(18) (250 × 4.6 mm i.d, 5 μm particle size) column at room temperature. The mean accuracy of analytical method were 94.92 %, 95.38 %, 94.67 % and 96.90 % in straw, grain, soil and field water respectively. The precision (repeatability) was found in the range of 1.30 %-9.25 % for straw/grain, 1.27 %-11.19 % in soil; 1.0 %-9.25 % in field water. The precision (reproducibility) in straw/grain was ranging from 2.2 % to 12.1 %, in soil it from 2.0 % to 11.7 %. The minimum detectable concentration was 0.01 mg kg(-1). The degradation of Chromafenozide formulation in rice, soil and water was determined and results showed that Chromafenozide as wettable powder formulation degraded with the half-lives of about 4.4 and 2.9 days in paddy plant and soil respectively for double recommended dose. The results indicated that the developed method is easier and faster then could meet the requirements for determination of Chromafenozide in paddy.
Nonsteroidal ecdysone agonists
Vitam Horm 2005;73:131-73.PMID:16399410DOI:10.1016/S0083-6729(05)73005-3.
Nonsteroidal ecdysone agonists are novel compounds that have become attractive candidates not only as pest control agents in agriculture but also as tools for research. Their narrow spectrum of activity makes them relatively safe as pesticides, and their mode of action as ligands for gene expression has found application in gene therapy and inducing transgenic gene expression in plants. These diacylhydrazines (DAHs) are potent nonsteroidal ecdysone agonists, and four of them, tebufenozide, methoxyfenozide, Chromafenozide, and halofenozide, have been developed as insecticides. Although these compounds are very toxic to insects, they are safe for mammals and are environmentally benign. Their action on insects is also selective, the first three are effective against Lepidoptera but weakly active or inactive on Diptera and Coleoptera. On the other hand, halofenozide is effective on Coleoptera but mildly active on Lepidoptera. Previous reviews on ecdysone agonists have concentrated on the biological response of some DAHs and their effects on pests. In this review, the chemistry, biological effects and their modes of action at the molecular level will be covered. In addition, a few studies on other nonsteroidal ecdysone agonists, such as 3,5-di-tert-butyl-4-hydroxy-N-iso-butylbenzamide, acylaminoketones, and benzoyl-1,2,3,4-tetrahydroquinolines, will be briefly reviewed.