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Chrysophanol triglucoside Sale

(Synonyms: 大黄酚-1-O-Β-三葡萄糖苷) 目录号 : GC60706

Chrysophanoltriglucoside是一种从决明子中分离出的蒽醌类化合物,可抑制蛋白酪氨酸磷酸酶1B(PTP1B)和α-glucosidase,IC50值分别为80.17和197.06µM。Chrysophanoltriglucoside具有糖尿病研究的潜力。

Chrysophanol triglucoside Chemical Structure

Cas No.:120181-07-9

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产品描述

Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia, inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC50s of 80.17 and 197.06 µM, respectively. Chrysophanol triglucoside has the potential for diabetes research[1].

[1]. Jung HA, et, al. Promising Inhibitory Effects of Anthraquinones, Naphthopyrone, and Naphthalene Glycosides, from Cassia obtusifolia on α-Glucosidase and Human Protein Tyrosine Phosphatases 1B. Molecules. 2016 Dec 27; 22(1): 28.

Chemical Properties

Cas No. 120181-07-9 SDF
别名 大黄酚-1-O-Β-三葡萄糖苷
Canonical SMILES O=C(C1=C2O)C(C(C(C1=CC=C2)=O)=CC(C)=C3)=C3O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)CO[C@H](O[C@@H]5CO)[C@@H]([C@H]([C@@H]5O)O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]([C@H]6O)CO)O
分子式 C33H40O19 分子量 740.66
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10 mM 0.135 mL 0.6751 mL 1.3501 mL
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Research Update

Inhibitory activities of Cassia tora and its anthraquinone constituents on angiotensin-converting enzyme

Phytother Res 2009 Feb;23(2):178-84.PMID:18803227DOI:10.1002/ptr.2579

As a component of our program that pertains to the isolation of antihypertensive agents derived from natural products, we screened the bioactivity of seeds from raw and roasted Cassia tora via angiotensin converting enzyme (ACE) inhibitory assays. We found that both of the MeOH extracts from the raw and roasted C. tora exhibited significant inhibitory properties against ACE, demonstrating more than 50% inhibition at a concentration of 163.93 microg/mL. Emodin (3), alaternin (4), gluco-obtusifolin (5), cassiaside (6), gluco-aurantioobtusin (7), cassitoroside (8), toralactone gentiobioside (9), and Chrysophanol triglucoside (10) had been previously isolated; however, questin (1) and 2-hydroxyemodin 1-methylether (2) were isolated from C. tora for the first time in this study. Among them, only anthraquinone glycoside (7) demonstrated marked inhibitory activity against ACE, with an IC(50) value of 30.24 +/- 0.20 microM. Conversely, aurantioobtusin (7a), obtained from the acid hydrolysis of 7, showed no activity. Further inhibitory kinetics analyzed from Lineweaver-Burk plots showed 7 to be a competitive inhibitor with a Ki value of 8.3 x 10(-5) M. Moreover, compound 7 showed marked inhibitory and scavenging activities with an IC(50) value of 49.64 +/- 0.37 microM (positive control; trolox: 26.07 +/- 1.05 microM) for total reactive oxygen species generation, and 4.60 +/- 1.12 microM (positive control; penicillamine: 0.24 +/- 0.04 microM) for ONOO(-).