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Ciproxifan maleate Sale

(Synonyms: 环丙基[4-[3-(1H-咪唑-4-基)丙氧基]苯基]甲酮马来酸盐,FUB 359 maleate) 目录号 : GC15847

A histamine H3 receptor antagonist

Ciproxifan maleate Chemical Structure

Cas No.:184025-19-2

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5mg
¥599.00
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25mg
¥1,911.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.IC50 value: Target: H3 receptorIn vitro, Ciproxifan behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. This appears to be an orally bioavailable, extremely selective and potent H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

References:
[1]. Motawaj M, Arrang JM.Ciproxifan, a histamine H -receptor antagonist / inverse agonist, modulates methamphetamine-induced sensitization in mice.Eur J Neurosci. 2011 Apr;33(7):1197-204. doi: 10.1111/j.1460-9568.2011.07618.x.
[2]. Bardgett ME, Davis NN, Schultheis PJ, Griffith MS. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72.
[3]. Bardgett ME, Points M, Kleier J, Blankenship M, Griffith MS. The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats. Neuropharmacology. 2010 Nov;59(6):492-502.
[4]. Day M, et al . Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test. Biochem Pharmacol. 2007 Apr 15;73(8):1123-34.
[5]. Pillot C, Héron A, Schwartz JC, Arrang JM. Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum. Eur J Neurosci. 2003 Jan;17(2):307-14.

Chemical Properties

Cas No. 184025-19-2 SDF
别名 环丙基[4-[3-(1H-咪唑-4-基)丙氧基]苯基]甲酮马来酸盐,FUB 359 maleate
化学名 (Z)-but-2-enedioic acid;cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone
Canonical SMILES C1CC1C(=O)C2=CC=C(C=C2)OCCCC3=CN=CN3.C(=CC(=O)O)C(=O)O
分子式 C20H22N2O6 分子量 386.4
溶解度 DMSO : ≥ 100 mg/mL (258.80 mM); H2O : 3.57 mg/mL (9.24 mM; ultrasonic and warming and heat to 60°C) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.588 mL 12.94 mL 25.8799 mL
5 mM 0.5176 mL 2.588 mL 5.176 mL
10 mM 0.2588 mL 1.294 mL 2.588 mL
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