Clerodendrin
目录号 : GC67859Clerodendrin 是一种可从 Lobelia chinensis 中分离得到的天然产物。Clerodendrin 是一种有效的双重白介素-4 (IL-4) 抑制剂和 β-己糖氨基苷酶 (Hex) 抑制剂。
Cas No.:119738-57-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Clerodendrin is a nature product could be isolated from Lobelia chinensis. Clerodendrin is a potent dual Interleukin-4 (IL-4) inhibitor and β-hexosaminidase (Hex) inhibitor[1].
Clerodendrin (10 μM; 1 and 3 h) inhibits IL-4 mRNA expression and the release of β-hexosaminidase in Propidium Iodide -induced RBL-2H3 cells[1].
[1]. Young KT, et, al. Inhibition of Interleukin-4 and β-Hexosaminidase Release in RBL-2H3 Cells by Compounds Isolated from Lobelia chinensis. 2021,27(4):251-6.
| Cas No. | 119738-57-7 | SDF | Download SDF |
| 分子式 | C27H26O17 | 分子量 | 622.49 |
| 溶解度 | DMSO : 50 mg/mL (80.32 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6065 mL | 8.0323 mL | 16.0645 mL |
| 5 mM | 0.3213 mL | 1.6065 mL | 3.2129 mL |
| 10 mM | 0.1606 mL | 0.8032 mL | 1.6065 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Clerodendrin I, a New Neoclerodane Diterpenoid from Clerodendron trichotomum
Biosci Biotechnol Biochem 1999;63(10):1795-7.PMID:26300171DOI:10.1271/bbb.63.1795.
A new neoclerodane diterpenoid, Clerodendrin I, was isolated from leaves of Clerodendron trichotomum as a feeding stimulant of the turnip sawfly, Athalia rosae ruficornis, and characterized as a threo epimer of Clerodendrin F in the 2,3-diacetoxy-2-methylbutanoyloxy moiety at the C-3β position.
Comprehensive review of Clerodendrum phlomidis: a traditionally used bitter
Zhong Xi Yi Jie He Xue Bao 2010 Jun;8(6):510-24.PMID:20550872DOI:10.3736/jcim20100602.
Clerodendrum phlomidis Linn. f., (syn. Clerodendrum multiflorum (Burm.f) O. Kuntze, Volkameria multiflorum Burm. f.) (Lamiaceae) is an important and well known medicinal plant extensively used in Ayurveda and Siddha system of medicine for treatment of various ailments. The popular therapies include on inflammation, diabetes, nervous disorder, asthma, rheumatism, digestive disorders, and urinary disorders as well as a bitter tonic. It was reported that pectolinaringenin, scutellarein, clerodin, Clerodendrin, clerosterol, 24beta-ethylcholesta-5,22E,25-triene-3beta-ol, lup-20(29)-en-3-triacontanoate, 4,2',4'-trihydroxy-6'-methoxychalcone-4,4'alpha-D-diglucoside, 7-hydroxyflavone, 7-hydroxyflavanone-7-O-glucoside and alpha-L-rhamnopyranosyl-(1-2)alpha-D-glucopyranosyl-7-O-naringin-4'-O-alpha-D-glucopyranoside-5-methyl ether had been isolated from this plant. The alcoholic and aqueous extracts were reported active as analgesic, antidiarrhoeal, antiplasmodial, hypoglycemic, minor tranquilizers, anti-asthmatic, antifungal, nematicidal, anti-amnestic and anti-arthritic. There are coincidences between some of the traditional usages of this plant and experimentally observed effects of the extracts but very few biological studies available on bioactive fractions and/or pure compounds. This review is an attempt to compile the exhaustive literature on Clerodendrum phlomidis, to highlight, analyze and critically assess the pharmaceutical potential of this underestimated plant in a systematic way.
Antifeedant and growth inhibitory effects of some neo-clerodane diterpenoids isolated from Clerodendron species (Verbenaceae) on Earias vitella and Spodoptera litura
J Agric Food Chem 2003 Mar 12;51(6):1555-9.PMID:12617583DOI:10.1021/jf025920a.
Antifeedant and growth inhibitory effects of various neo-clerodane diterpenoids having a furofuran moiety, isolated from Clerodendron spp., were studied using Earias vitella and Spodoptera litura. The compounds Clerodendrin B, 3-epicaryoptin, 15-hydroxyepicaryoptin, and clerodin were effective antifeedants at 10 microg/cm(3) (30 microg/g) of diet against E. vitella and at 10 microg/cm(2) of leaf against S. litura. All of the tested compounds, namely, Clerodendrin B, 3-epicaryoptin, Clerodendrin C, 15-hydroxyepicaryoptin, Clerodendrin B acetate, and clerodin, showed good insect growth inhibitory activity even at lower concentrations.