CNDP1 Human
目录号 : GP21488CNDP Dipeptidase 1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greaterthan 95.0% as determined by SDS-PAGE. | Source | Sf9,Insect cells. |
| Phycical Appearance | Sterilefiltered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | CarnosineDipeptidase 1 (Metallopeptidase M20 Family); Glutamate Carboxypeptidase-LikeProtein 2; CNDP Dipeptidase 1; Serum Carnosinase; Carnosinase 1; CPGL2; CN1;Carnosine Dipeptidase 1; EC 3.4.13.20; HsT2308. | ||
| Amino Acid Sequence | SPSPPPALLE KVFQYIDLHQ DEFVQTLKEW VAIESDSVQP VPRFRQELFR MMAVAADTLQ RLGARVASVD MGPQQLPDGQ SLPIPPVILA ELGSDPTKGT VCFYGHLDVQ PADRGDGWLT DPYVLTEVDG KLYGRGATDN KGPVLAWINA VSAFRALEQD LPVNIKFIIE GMEEAGSVAL EELVEKEKDR FFSGVDYIVI SDNLWISQRK PAITYGTRGN SYFMVEVKCR DQDFHSGTFG GILHEPMADL VALLGSLVDS SGHILVPGIY DEVVPLTEEE INTYKAIHLD LEEYRNSSRV EKFLFDTKEE ILMHLWRYPS LSIHGIEGAF DEPGTKTVIP GRVIGKFSIR LVPHMNVSAV EKQVTRHLED VFSKRNSSNK MVVSMTLGLH PWIANIDDTQ YLAAKRAIRT VFGTEPDMIR DGSTIPIAKM FQEIVHKSVV LIPLGAVDDG EHSQNEKINR WNYIEGTKLF AAFFLEMAQL HLEHHHHHH. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | CNDP1protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and10% glycerol. | ||
CNDP Dipeptidase 1, also known as CNDP1 is a member of the peptidaseM20A family. CNDP1 Mannheim which is the shortest allelic form has been morecommon in the absence of nephropathy in addition to being associated with lower serum carnosinase levels. Furthermore, Carnosine inhibited the increasedproduction of fibronectin as well as collagen type VI in podocytes and theincreased production of TGF-beta in mesangial cells. Diabetic patients with theCNDP1 Mannheim variant are less at risk for nephropathy. In addition, on renalcells carnosine protects against the adverse effects of high glucose levels.
Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.