Coenzyme Q9 (Ubiquinone Q9)
(Synonyms: 辅酶Q9; Ubiquinone Q9; CoQ9; Ubiquinone 9) 目录号 : GC32470
A mitochondrial ubiquinone
Cas No.:303-97-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Coenzyme Q9 (CoQ9) is a mitochondrial ubiquinone with a role in the electron transport chain.1 It reduces the incidence of ischemia and reperfusion-induced arrhythmia and improves post-ischemic heart rate, coronary flow, aortic flow, and left ventricular developed pressure in isolated guinea pig hearts when used at a dose of 5 mg/kg.1 CoQ9 (5 mg/kg) also reduces ischemia and reperfusion-induced myocardial infarct size and the number of apoptotic cardiomyocytes in the same model.
1.Lekli, I., Das, S., Das, S., et al.Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10J. Agric. Food Chem.56(13)5331-5337(2008)
| Cas No. | 303-97-9 | SDF | |
| 别名 | 辅酶Q9; Ubiquinone Q9; CoQ9; Ubiquinone 9 | ||
| Canonical SMILES | O=C1C(OC)=C(OC)C(C(C)=C1C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=O | ||
| 分子式 | C54H82O4 | 分子量 | 795.23 |
| 溶解度 | DMSO : 5 mg/mL (6.29 mM);Water : < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.2575 mL | 6.2875 mL | 12.575 mL |
| 5 mM | 0.2515 mL | 1.2575 mL | 2.515 mL |
| 10 mM | 0.1257 mL | 0.6287 mL | 1.2575 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Protective effect of ubiquinone (Coenzyme Q9) on ascites in broiler chickens
Br Poult Sci 1996 Mar;37(1):189-95.PMID:8833538DOI:10.1080/00071669608417847.
1. The effect of ubiquinone (CoQ(9)) on ascites in broiler chickens was investigated. 2. The commercial broilers were divided into 2 groups of 100 birds each; CoQ(9) treated group and non-treated group. 3. The chickens were grown in a positive-pressured house with double high efficiency particulate air filtered intakes and exhaust, and thus were strictly isolated from infectious agents. 4. The chickens (15 to 21 d old) were exposed to cold stress in order to induce ascites. 5. The number of birds with ascites in the CoQ(9)-treated group was significantly lower than in the non-treated group. 6. Survival and production rates were better in the CoQ(9)-treated group than in the non-treated group.
Factors Influencing the Contents of Coenzyme Q10 and Q9 in Olive Oils
J Agric Food Chem 2014 Apr 9;62(14):3211-3216.PMID:24650117DOI:10.1021/jf5002167.
The health effects of olive oil are attributed to its high content of oleic acid and other constituents, particularly its phenolic fraction. Olive oil also contains other substances with potential health effects such as coenzyme Q10 (CoQ10) and Coenzyme Q9 (CoQ9). The objective of our study was to investigate some factors that could influence the quantity of coenzyme Q (CoQ) in olive oils. We analyzed almost 100 samples of commercial oil blends and fresh extra virgin olive oils of various cultivars using high-performance liquid chromatography. With the investigation of various monocultivar samples we determined that genetic parameters (cultivars) have an important influence on the composition of olive oils, particularly the content of CoQ10. Possible effects of the degree of ripeness were also studied for the cultivars Istrska belica and Leccino. We determined that the highest levels of both CoQ10 and CoQ9 can be found in early maturation stages.
Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10
J Agric Food Chem 2008 Jul 9;56(13):5331-7.PMID:18543930DOI:10.1021/jf800035f.
Coenzyme Q10 (CoQ10) has been extensively studied as adjunctive therapy for ischemic heart disease, and its cardioprotective ability is well-established. The mitochondrial respiratory chain contains several coenzymes, including CoQ1, CoQ2, CoQ4, CoQ6, CoQ7, CoQ8, CoQ9, and CoQ10. It is not known whether other CoQs, especially CoQ9, is equally cardioprotective as CoQ10. The present study was designed to determine if CoQ 9 could protect guinea pig hearts from ischemia reperfusion injury. Guinea pigs were randomly divided into three groups: groups I and II were fed CoQ 9 and CoQ10, respectively, for 30 days while group III served as control. After 30 days, the guinea pigs were sacrificed and isolated hearts were perfused via working mode were subjected to 30 min ischemia followed by 2 h of reperfusion. Cardioprotection was assessed by evaluating left ventricular function, ventricular arrhythmias, myocardial infarct size, and cardiomyocyte apoptosis. Samples of hearts were examined for the presence of CoQ9 and CoQ10. The results demonstrated that both CoQ9 and CoQ10 were equally cardioprotective, as evidenced by their abilities to improve left ventricular performance and to reduce myocardial infarct size and cardiomyocyte apoptosis. High performance liquid chromatographic (HPLC) analysis revealed that a substantial portion of CoQ9 had been converted into CoQ10. The results indicate that CoQ9 by itself, or after being converted into CoQ10, reduced myocardial ischemia/reperfusion-induced injury.
Determination of coenzyme Q10, Coenzyme Q9, and melatonin contents in virgin argan oils: comparison with other edible vegetable oils
J Agric Food Chem 2011 Nov 23;59(22):12102-8.PMID:22007968DOI:10.1021/jf203428t.
Virgin argan oil possesses high antioxidant capacity (AC), which may be partially explained by its high content in antioxidant molecules such as polyphenols and tocopherols. However, the content in other antioxidant molecules, for example, coenzyme Q10 (CoQ(10)), Coenzyme Q9 (CoQ(9)), and melatonin (Mel), which have been identified in other edible vegetable oils, have not been evaluated in virgin argan oil. Consequently, it was decided to evaluate the contents of CoQ(10), CoQ(9), and Mel in virgin argan oils and compare the results to those obtained in extra virgin olive oils and some varieties of seed oils. By the use of sensitive HPLC-EC/F methods, the results showed that virgin argan oil is a rich source of CoQ(10) and Mel, but no CoQ(9) was detected. Extra virgin olive oil showed higher levels of CoQ(10) and lower levels of Mel than virgin argan oil. Between the seed oil samples, only virgin soybean oil showed higher CoQ(10) and Mel levels than virgin argan oil. The results may be relevant for the contribution of CoQ(10) and Mel to the biological activities of virgin argan oil.
Determination of coenzyme Q10 and Q9 in vegetable oils
J Agric Food Chem 2008 Aug 13;56(15):6241-5.PMID:18616270DOI:10.1021/jf800103e.
A new sensitive and selective method has been developed for the quantification of the total Coenzyme Q9 (CoQ9) and coenzyme Q10 (CoQ10) concentration in vegetable oil samples. The coenzyme Q fraction is isolated by solid-phase extraction (SPE) on amino phase eluting with a mixture of heptane:ethyl ether. The organic solvent is evaporated under nitrogen, and the residue is dissolved in a mixture of acetonitrile:tetrahydrofuran and finally is analyzed by reverse-phase high-performance liquid chromatography with a mass detector. The sensitivity of the method is based on the high efficient formation of the radical anions [M (-.)] of CoQ9 and CoQ10 by negative atmospheric pressure ionization. Interferences are minimized by using mass detection of the [M (-.)] ions ( m/ z = 797.5 for CoQ9 and m/ z = 862.5 for CoQ10) in selective reaction monitoring mode ( m/ z = 797.5 --> m/ z = 779.5 and m/ z = 862.5 --> m/ z = 847.5) using a triple-quadrupole mass spectrometer. The method was successfully applied to sunflower, soybean, and rapeseed oils, with a limit of quantification of 0.025 mg/kg for both compounds.