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Collagen proline hydroxylase inhibitor Sale

(Synonyms: 胶原蛋白脯氨酸羟化酶抑制剂) 目录号 : GC11075

胶原脯氨酸羟化酶抑制剂是胶原脯氨酸羟化酶抑制剂;可用于抗纤维增殖剂。

Collagen proline hydroxylase inhibitor Chemical Structure

Cas No.:223666-07-7

规格 价格 库存 购买数量
5mg
¥2,880.00
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Sample solution is provided at 25 µL, 10mM.

Description

IC50: N/A

Collagen proline hydroxylase inhibitor is one member of the collagen proline hydroxylase inhibitor family, which are used as antifibroproliferative agents. Proline hydroxylase is a multiple function oxygenase catalyzing specific prolyl residues in the collagen peptide precursor. Proline hydroxylase has been known as one of the critical enzymes in the biosynthesis of collagen and its activity is enhanced in tissues of various pathological fibrosis. Thus, the specific inhibitor of proline hydroxylase could have clinical application in fibrotic diseases treatment.

In vitro: One of collagen proline hydroxylase inhibitors, P-1894B, was found to in vitro inhibit proline hydroxylase and had been proposed as a topical treatment for dermal fibrosis. P-1894B was observed to be with similar activities on one fibroblast line from a patient with infection and two fibroblast lines from normal human skin. 72-hour drug exposure on growing cells showed both time- and dose-dependent inhibition of proliferation. A similar result was also observed in the epithelial cell line NCTC 2544 [1].

In vivo: So far, collagen proline hydroxylase inhibitor has not been applied to animal in vivo study.

Clinical trial: Currently, no clinical study is available.

Reference:
[1] Priestley GC.  Toxicity of the anthraquinone glycoside P-1894B for human skin fibroblasts. Br J Dermatol.1987 Jul;117(1):67-72.

化学性质

Cas No. 223666-07-7 SDF
别名 胶原蛋白脯氨酸羟化酶抑制剂
化学名 N-ethyl-8-nitro-7-oxo-N-propyl-7,10-dihydro-1,10-phenanthroline-3-carboxamide
Canonical SMILES CCCN(C(C1=CN=C2C(C=CC3=C2NC=C([N+]([O-])=O)C3=O)=C1)=O)CC
分子式 C18H18N4O4 分子量 354.36
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.822 mL 14.1099 mL 28.2199 mL
5 mM 0.5644 mL 2.822 mL 5.644 mL
10 mM 0.2822 mL 1.411 mL 2.822 mL
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