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Collismycin A Sale

(Synonyms: 碰撞霉素A) 目录号 : GC43299

A bacterial metabolite with diverse biological activities

Collismycin A Chemical Structure

Cas No.:158792-24-6

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1mg
¥5,567.00
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5mg
¥16,702.00
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Sample solution is provided at 25 µL, 10mM.

Description

Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 µg/ml) and fungi (MICs = 12.5-100 µg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 µM, respectively) and NIH373 fibroblasts (IC50 = 56.6 µM) but not MDA-MD-231 breast cancer cells (IC50 = >100 µM). Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions. Collismycin A (1 µM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid .

化学性质

Cas No. 158792-24-6 SDF
别名 碰撞霉素A
Canonical SMILES COC1=C(SC)C(/C=N/O)=NC(C2=NC=CC=C2)=C1
分子式 C13H13N3O2S 分子量 275.3
溶解度 DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.6324 mL 18.162 mL 36.324 mL
5 mM 0.7265 mL 3.6324 mL 7.2648 mL
10 mM 0.3632 mL 1.8162 mL 3.6324 mL
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