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Conglobatin Sale

目录号 : GC18832

An Hsp90 inhibitor

Conglobatin Chemical Structure

Cas No.:72263-05-9

规格 价格 库存 购买数量
500μg
¥4,109.00
现货
2.5mg
¥16,385.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus. It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells. It also inhibits cell proliferation in HER2+ breast cancer cell lines (IC50s = 12.9-61.5 uM, respectively) and decreases the number of invasive cells in vitro. When combined with lapatinib , tumor growth of SK-BR-3 mouse xenografts was reduced to a greater degree than with conglobatin alone. Conglobatin has various anticancer effects in esophageal squamous cell carcinoma (ESCC) models as well, including an inhibition of cell proliferation in KYSE510 cells (IC50 = 9.31 uM). It also inhibits β1 integrin activation leading to a loss of cellular adhesion.

Chemical Properties

Cas No. 72263-05-9 SDF
化学名 (3E,5R,11E)-3,5,7S,11,13R,15S-hexamethyl-8S,16S-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
Canonical SMILES C[C@H]([C@H](CC1=CN=CO1)OC(/C(C)=C/[C@H](C)C[C@H](C)[C@H](CC2=CN=CO2)O3)=O)C[C@@H](C)/C=C(C)\C3=O
分子式 C28H38N2O6 分子量 498.6
溶解度 DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.0056 mL 10.0281 mL 20.0562 mL
5 mM 0.4011 mL 2.0056 mL 4.0112 mL
10 mM 0.2006 mL 1.0028 mL 2.0056 mL
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