Conoidin A
(Synonyms: 1,4-二氧代-2,3-二溴甲基喹啉) 目录号 : GC15562
A peroxiredoxin inhibitor
Cas No.:18080-67-6
Sample solution is provided at 25 µL, 10mM.
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Conoidin A is a covalent inhibitor of peroxiredoxin II with IC50 value of 23 μM [2].
Peroxiredoxins are a widely conserved family of enzymes that function in antioxidant defense and signal transduction, and changes in PrxII expression are associated with a variety of human diseases, including cancer [1].
Conoidin A is a novel, cell-permeable and covalent peroxiredoxin II inhibitor with IC50 value of 23 μM [1][2]. Conoidin A bound covalently to the peroxidatic cysteine of the T. gondii enzyme peroxiredoxin II (TgPrxII), inhibiting its enzymatic activity. In human epithelial cells, Conoidin A inhibited hyperoxidation of human PrxII [1]. Conoidin A also inactivated AcePrx-1 (a peroxiredoxin from the hookworm Ancylostoma ceylanicum) by alkylating or crosslinking the catalytic cysteines with IC50 value of 374 μM [2]. Conoidin A inhibited the hyperoxidation of two mammalian peroxiredoxin homologues (PrxI and PrxII) in cells [3].
References:
[1]. Haraldsen JD1, Liu G, Botting CH, et al. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048.
[2]. Nguyen JB1, Pool CD, Wong CY, et al. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem Biol. 2013 Aug 22;20(8):991-1001.
[3]. Liu G, Botting CH, Evans KM, et al. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem. 2010 Jan;5(1):41-5.
| Cas No. | 18080-67-6 | SDF | |
| 别名 | 1,4-二氧代-2,3-二溴甲基喹啉 | ||
| 化学名 | 2,3-bis(bromomethyl)-quinoxaline 1,4-dioxide | ||
| Canonical SMILES | [O-][N+]1=C(CBr)C(CBr)=[N+]([O-])C2=C1C=CC=C2 | ||
| 分子式 | C10H8Br2N2O2 | 分子量 | 348.0 |
| 溶解度 | ≥ 34.8mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.8736 mL | 14.3678 mL | 28.7356 mL |
| 5 mM | 0.5747 mL | 2.8736 mL | 5.7471 mL |
| 10 mM | 0.2874 mL | 1.4368 mL | 2.8736 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet