Corn oil
(Synonyms: 玉米油) 目录号 : GC32712
玉米油是从玉米胚芽中提取出来的，可以用作药物分子的载体。
Cas No.:8001-30-7
Sample solution is provided at 25 µL, 10mM.
Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules and has anti-tumor activity.
Corn oil-gavaged rats have ~25% lower MNCL incidence as well as longer MNCL latency and increase survival. Corn oil-gavaged rats have 54% lower serum growth hormone (GH) levels, and replacement of GH into corn oil-gavaged rats by osmotic minipump infusion increase in situ MNCL cell proliferation to rates observed in water-gavaged animals. Corn oil-gavaged rats, which receive 5 mL corn oil /kg body wt/day for 5 days/week, have a 3-fold increase in fat intake compared to nongavaged or water-gavaged control rats[1]. Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40u201350 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats result in a marked decrease in the growth rate of both tumors[2].
玉米油是从玉米胚芽中提取出来的，可以作为药物分子的载体，并具有抗肿瘤活性。
给老鼠灌注玉米油可以降低MNCL的发生率约25％，延长MNCL潜伏期并增加存活率。接受玉米油灌胃的老鼠血清中生长激素（GH）水平下降54％，将GH替换到通过渗透压微泵输注玉米油的老鼠体内会使原位MNCL细胞增殖速度达到与喝水控制组动物相同的水平。每周5天，每天给予5毫升/公斤体重的玉米油灌胃后，与未经过或仅喝水控制组老鼠相比，其脂肪摄入量增加了3倍[1]。在成年雄性野牛大鼠大腿注射肝癌7777或7800组织40-50毫克前和后微量注射玉米油可显着减缓两种肿瘤的生长速度[2]。
[1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9.
[2]. Gilbertson JR, et al. Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil. Oncology. 1977;34(2):62-4.
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Animal experiment: |
Rats[1]Male and female F344 rats (50 days of age are individually housed in polycarbonate cages on hardwood bedding in rooms maintained at 24°C with 12 h light/dark cycles. All rats are given unlimited access to distilled water and NIH-07 open formula diet. Orally gavaged animals receive corn oil or distilled water 5 days/week at a volume of 5 mL/kg body wt/day[1]. |
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References: [1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9. |
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| Cas No. | 8001-30-7 | SDF | |
| 别名 | 玉米油 | ||
| Canonical SMILES | [Corn oil] | ||
| 分子式 | 分子量 | ||
| 溶解度 | Ethanol: 10 mg/mL | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet