Corn oil
(Synonyms: 玉米油) 目录号 : GC32712
玉米油是从玉米胚芽中提取出来的，可以用作药物分子的载体。
Cas No.:8001-30-7
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
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- SDS (Safety Data Sheet)
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Animal experiment: |
Rats[1]Male and female F344 rats (50 days of age are individually housed in polycarbonate cages on hardwood bedding in rooms maintained at 24°C with 12 h light/dark cycles. All rats are given unlimited access to distilled water and NIH-07 open formula diet. Orally gavaged animals receive corn oil or distilled water 5 days/week at a volume of 5 mL/kg body wt/day[1]. |
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References: [1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9. |
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Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules and has anti-tumor activity.
Corn oil-gavaged rats have ~25% lower MNCL incidence as well as longer MNCL latency and increase survival. Corn oil-gavaged rats have 54% lower serum growth hormone (GH) levels, and replacement of GH into corn oil-gavaged rats by osmotic minipump infusion increase in situ MNCL cell proliferation to rates observed in water-gavaged animals. Corn oil-gavaged rats, which receive 5 mL corn oil /kg body wt/day for 5 days/week, have a 3-fold increase in fat intake compared to nongavaged or water-gavaged control rats[1]. Intraperitoneal injection of trace amounts of corn oil prior to and following the injection of 40u201350 mg of tissue from hepatoma 7777 or 7800 into the thigh of adult male Buffalo rats result in a marked decrease in the growth rate of both tumors[2].
玉米油是从玉米胚芽中提取出来的，可以作为药物分子的载体，并具有抗肿瘤活性。
给老鼠灌注玉米油可以降低MNCL的发生率约25％，延长MNCL潜伏期并增加存活率。接受玉米油灌胃的老鼠血清中生长激素（GH）水平下降54％，将GH替换到通过渗透压微泵输注玉米油的老鼠体内会使原位MNCL细胞增殖速度达到与喝水控制组动物相同的水平。每周5天，每天给予5毫升/公斤体重的玉米油灌胃后，与未经过或仅喝水控制组老鼠相比，其脂肪摄入量增加了3倍[1]。在成年雄性野牛大鼠大腿注射肝癌7777或7800组织40-50毫克前和后微量注射玉米油可显着减缓两种肿瘤的生长速度[2]。
[1]. Hursting SD, et al. Inhibition of rat mononuclear cell leukemia by corn oil gavage: in vivo, in situ and immune competence studies. Carcinogenesis. 1994 Feb;15(2):193-9.
[2]. Gilbertson JR, et al. Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil. Oncology. 1977;34(2):62-4.
| Cas No. | 8001-30-7 | SDF | |
| 别名 | 玉米油 | ||
| Canonical SMILES | [Corn oil] | ||
| 分子式 | 分子量 | ||
| 溶解度 | Ethanol: 10 mg/mL | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Effects of naturally oxidized Corn oil on inflammatory reaction and intestinal health of broilers
Poult Sci 2022 Jan;101(1):101541.PMID:34788712DOI:10.1016/j.psj.2021.101541.
This study was conducted to investigate the effects of naturally oxidized Corn oil on the inflammatory reaction and intestinal health of broilers. Total 450, one-day-old Arbor Acres male broilers were randomly divided into 5 treatments with 6 replicate cages (15 birds in each replicate cage). The dietary treatment array consisted of the varying ratio of nonoxidized Corn oil to naturally oxidized Corn oil from 0:100, 25:75, 50:50, 75:25, and 100:0, respectively. The experimental period was 42 d. Serum, jejunum, and contents of cecum samples were taken at the age of 42 d of broilers. The results showed no significant difference in the body weight gain (BWG) with a different proportion of oxidized Corn oil compared with the 0% oxidized oil group on d 42. The feed intake (FI), the concentration of immunoglobulin G (IgG), interferon-γ (IFN-γ), and interleukin-10 (IL10) in serum showed a significant quadratic response with the increase of oxidized oil concentration on d 42. The serum's concentration of IgG, IFN-γ, and IL-10 reached the highest value at 75% oxidized Corn oil. In addition, the mRNA expression levels of interleukin-1β (IL-1β), IFN-γ, nuclear factor kappa B (NF-κB), tumor necrosis factor α (TNF-α), and myeloid differentiation factor-88 (MyD88) in the jejunum were significantly affected by different proportions of oxidized Corn oil, and the gene expression levels were highest at 75% oxidized Corn oil on d 42. The mRNA expression of Bcl2-associated X (Bax) in the jejunum showed a significantly quadratic curve with the increase of oxidized oil concentration, and its gene expression was the highest after adding 50% oxidized Corn oil according to the regression equation on d 42. The villus height/crypt depth and goblet cells of jejunum decreased linearly with the increasing proportion of oxidized Corn oil and reached the lowest point after adding 100% oxidized Corn oil on d 42. The β diversity showed the remarkable differentiation of microbial communities among 5 groups, and the microbial community of the 0% oxidized oil group was significantly separated from that of 75 and 100% oxidized oil groups in the cecum. Taken together, these results showed that a low dose of naturally oxidized Corn oil is not harmful to the growth of broilers, while a high dose of oxidized Corn oil will trigger the inflammatory response and adversely affect the gut health of broilers.
Characterization of Corn oil Using Fluorescence Spectroscopy
J Fluoresc 2022 Nov;32(6):1977-1989.PMID:35789318DOI:10.1007/s10895-022-02997-0.
In these studies, Fluorescence spectroscopy has been utilized for the characterization of pure and commercially available Corn oil. The best excitation wavelength of 380 nm has been investigated, where maximum spectral information can be assessed. The emission spectra from pure and commercial Corn oil samples disclosed that pure Corn oil contained oleic acid, beta-carotenes, chlorophylls, isomers of vitamin E and traces of oxidized products which exhibit fluorescence at 406, 525, 675, 440 and 435/475 nm respectively. Whereas, commercial corn oils lack these valuable ingredients and only contain fats along with their primary and secondary oxidized products that emit a broad emission band centred at 440 nm. The study has also depicted that Fluorescence spectroscopy can even be used to select best quality Corn oil among pure Corn oil samples with different varieties and seed origins. In addition, the effect of temperature on the composition of pure and commercial Corn oil samples have also been investigated by heating them at 100, 120,140, 160, 180 and 200 °C each sample for 30 min. This was done because Corn oil is being used for cooking where it is generally heated up to 120 °C and for deep frying up to 180 °C. On heating, in pure Corn oil, deterioration of Vitamin-E and beta-carotenes occurred with an increase in the oxidation products, whereas, in commercial oil samples, only the concentration of oxidation products increased. However, it was found that up to 140 °C, pure Corn oil can be used safely for cooking purpose where it does not lose much of its valuable ingredients while in commercial corn oils, fat composition does not alter much up to 180 °C and after that oxidized products start to increase rapidly.
A comparative study between olive oil and Corn oil on oxidative metabolism
Food Funct 2022 Jul 4;13(13):7157-7167.PMID:35699154DOI:10.1039/d2fo00919f.
Fats are an important part of diet, but not all lipids have the same structure and chemical properties. Unsaturated fatty acids have one or more double bonds in their structure and can be monounsaturated or polyunsaturated, respectively. Most vegetable oils, such as olive oil and Corn oil, contain significant amounts of these fatty acids. The presence of double bonds in the molecule of a fatty acid constitutes vulnerable sites for oxidation reactions generating lipid peroxides, potentially toxic compounds that can cause cellular damage. In response to this oxidative damage, aerobic organisms have intracellular enzymatic antioxidant defense mechanisms. The aim of the present investigation was to study comparatively the effects of control liquid diets, of a defined composition, containing olive oil or Corn oil as a lipid source respectively of monounsaturated and polyunsaturated fatty acids, on the oxidative metabolism of rats. Rats were divided into three groups which received a control animal feed diet (A.F.), olive oil liquid diet (O.O) and Corn oil liquid diet (C.O) for 30 days. It was observed that the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), increased in the liver and white fat tissue of rats fed with olive oil when compared to the Corn oil group. However, in brown fat tissue and blood cells, the enzyme activities showed a tendency to decrease in the olive oil group. In addition, the effect of olive oil and Corn oil on several glucose metabolism parameters (pyruvate, lactate, LDH, acetoacetate and beta-hydroxybutyrate) showed that Corn oil impairs to a greater extent the cellular metabolism. All these results helped in concluding that some body tissues are more adversely affected than others by the administration of Corn oil or olive oil, and their antioxidant defenses and cellular metabolism respond differently too.
Heated Corn oil and 2,4-Decadienal Suppress Gastric Emptying and Energy Intake in Humans
Nutrients 2021 Apr 15;13(4):1304.PMID:33920888DOI:10.3390/nu13041304.
Consumption of 2,4-decadienal (2,4-DD) delays gastric emptying (GE) rate in animals. Oil heating produces 2,4-DD and other aldehydes. Here we examined whether heated oil affects GE rate and food intake in humans, and whether it is mediated by 2,4-DD. In the first experiment, 10 healthy volunteers consumed 240-g pumpkin soup with 9.2 g of heated (HO) or non-heated Corn oil (CO). Subsequently, 17 participants consumed pumpkin soup containing 3.1 g of either heated Corn oil (HO), 1 mg 2,4-DD + non-heated Corn oil (2,4-DD), or non-heated Corn oil (CO). Sixty minutes following pumpkin soup, cod roe spaghetti was provided, and then energy intake was determined. To evaluate GE rate, 13C breath test (Experiment 1) and ultrasonography (Experiments 1 and 2) were used. The results from the Experiment 1 confirmed that consumption of heated Corn oil reduced GE rate. Experiment 2 showed a delayed GE rate in HO and 2,4-DD trials compared with CO trial (p < 0.05). Energy intake was approximately 600-650 kJ lower in HO and 2,4-DD trials compared with CO trial (p < 0.05). These findings suggest that 2,4-DD, either formed by oil heating or added to food, contributes to suppressing GE rate and energy intake.
Zearalenone Removal from Corn oil by an Enzymatic Strategy
Toxins (Basel) 2020 Feb 13;12(2):117.PMID:32069863DOI:10.3390/toxins12020117.
The estrogen-like mycotoxin zearalenone (ZEN) is one of the most widely distributed contaminants especially in maize and its commodities, such as Corn oil. ZEN degrading enzymes possess the potential for counteracting the negative effect of ZEN and its associated high safety risk in Corn oil. Herein, we targeted enhancing the secretion of ZEN degrading enzyme by Pichia pastoris through constructing an expression plasmid containing three optimized expression cassettes of zlhy-6 codon and signal peptides. Further, we explored various parameters of enzymatic detoxification in neutralized oil and analyzed tocopherols and sterols losses in the Corn oil. In addition, the distribution of degraded products was demonstrated as well by Agilent 6510 Quadrupole Time-of-Flight mass spectrometry. P. pastoris GSZ with the glucoamylase signal was observed with the highest ZLHY-6 secretion yield of 0.39 mg/mL. During the refining of Corn oil, ZEN in the crude oil was reduced from 1257.3 to 13 µg/kg (3.69% residual) after neutralization and enzymatic detoxification. Compared with the neutralized oil, no significant difference in the total tocopherols and sterols contents was detected after enzymatic detoxification. Finally, the degraded products were found to be entirely eliminated by washing. This study presents an enzymatic strategy for efficient and safe ZEN removal with relatively low nutrient loss, which provides an important basis for further application of enzymatic ZEN elimination in the industrial process of Corn oil production.