CP 93,129
目录号 : GC91507CP 93,129 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B.
Cas No.:127792-75-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
CP 93,129 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B.[1] It selectively binds to 5-HT1B over 5-HT1A, 5-HT1C, 5-HT1D, and 5-HT2 receptors (Kis = 0.0081, 1.5, 2.9, 1.1, and 7.2 µM, respectively). CP 93,129 (5.4 µM) inhibits potassium-induced GABA release from rat globus pallidus slices.[2] It reverses akinesia in a rat model of Parkinson’s disease induced by reserpine when administered intrapallidally at doses of 110 and 220 nmol/animal. CP 93,129 reduces food intake in rats when infused into the pons parabrachial nucleus or the paraventricular nucleus (PVN) of the hypothalamus (ED50s = 1 and 50 nmol/animal, respectively).[3] It also reduces the frequency of pursuits, tail rattles, threats, and attack bites in a resident-intruder test in mice.[4]
References:
[1].Koe, B.K., Nielsen, J.A., Macor, J.E., et al.Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253Drug Dev. Res.26(3)241-250(1992).
[2].Chadha, A., Sur, C., Atack, J., et al.The 5HT1B receptor agonist, CP-93129, inhibits [3H]-GABA release from rat globus pallidus slices and reverses akinesia following intrapallidal injection in the reserpine-treated ratBr. J. Pharmacol.130(8)1927-1932(2000).
[3].Lee, M.D., Aloyo, V.J., Fluharty, S.J., et al.Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in ratsPsychopharmacology (Berl.)136(3)304-307(1997).
[4].Bannai, M., Fish, E.W., Faccidomo, S., et al.Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of micePsychopharmacology (Berl.)193(2)295-304(2007).
| Cas No. | 127792-75-0 | SDF | Download SDF |
| 分子式 | C12H13N3O | 分子量 | 215.3 |
| 溶解度 | Methanol: Slightly soluble: 0.1-1 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.6447 mL | 23.2234 mL | 46.4468 mL |
| 5 mM | 0.9289 mL | 4.6447 mL | 9.2894 mL |
| 10 mM | 0.4645 mL | 2.3223 mL | 4.6447 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。