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CV-6209-d5 Sale

目录号 : GC47135

A neuropeptide with diverse biological activities

CV-6209-d5 Chemical Structure

规格 价格 库存 购买数量
250 μg
¥2,399.00
现货
500 μg
¥3,854.00
现货
1 mg
¥6,853.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

CV-6209-d5 contains five deuterium atoms at the 1, 1, 2, 2, and 2 positions of the ethyl pyridinium moiety. It is intended for use as an internal standard for the quantification of CV-6209 by GC- or LC-mass spectrometry. CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM, respectively.1 It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen.1 CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid , histamine, bradykinin , or isoproterenol .1 CV-6209 is used to study the role of PAF receptor signaling in vitro and in vivo.2,3

1.Terashita, Z., Imura, Y., Takatani, M., et al.CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivoJournal of Pharmacology and Experimental Therapeutics242263-268(1987) 2.Leong, H.S., Mahesh, B.M., Day, J.R., et al.Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factorJournal of Leukocyte Biology83(2)263-271(2008) 3.Musio, S., Pedotti, P., Mantegazza, R., et al.Anaphylaxis to a self-peptide in the absence of mast cells or histamineLaboratory Investigation89(4)398-405(2009)

Chemical Properties

Cas No. N/A SDF
Canonical SMILES [2H]C([2H])([2H])C([2H])([2H])[N+]1=C(CN(C(C)=O)C(OCC(OC)COC(NCCCCCCCCCCCCCCCCCC)=O)=O)C=CC=C1.[Cl-]
分子式 C34H55D5N3O6.Cl 分子量 647.4
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.5446 mL 7.7232 mL 15.4464 mL
5 mM 0.3089 mL 1.5446 mL 3.0893 mL
10 mM 0.1545 mL 0.7723 mL 1.5446 mL
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