CXCL16 Human
目录号 : GP21080CXCL16 人类重组
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 97.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | Chemokine (C-X-C Motif) Ligand 16; Scavenger Receptor For Phosphatidylserine And Oxidized Low Density Lipoprotein; Transmembrane Chemokine CXCL16; Small-Inducible Cytokine B16; CXC Chemokine Ligand 16; SR-PSOX; SRPSOX; C-X-C Motif Chemokine 16; CXCLG16; SCYB16; CXCL16. | ||
| Amino Acid Sequence | NEGSVTGSCY CGKRISSDSP PSVQFMNRLR KHLRAYHRCL YYTRFQLLSW SVCGGNKDPW VQELMSCLDL KECGHAYSGI VAHQKHLLP. | ||
| Solubility | It is recommended to reconstitute the lyophilized CXCL16 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized CXCL16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution CXCL16 should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. | ||
| Biological Activity | The ED50, as measured by its ability to chemoattract mouse CXCR6-transfected mouse BaF3 cells, is less than 12ng/ml. | ||
| Formulation | CXCL16 protein was lyophilized from a 0.2µm filtered solution in PBS. | ||
CXC chemokine ligand 16 (CXCL16) is a type I membrane protein, which contains a non-ELR motif-containing CXC chemokine domain in its extracellular region. Human and Mouse CXCL16 share a 70% a.a. sequence similarity within their chemokine domains and 49% overall a.a. sequence identity. Functional CXCL16 can be dropped from the cell surface as an approximately 35kDa soluble protein. CXCR6 is the functional receptor for CXCL16. CXCL16 functions as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), proposing that CXCL16 may be involved in pathophysiology such as atherogenesis. In addition, CXCL16 induces a strong chemotactic response and calcium mobilization. CXCL16 binds to CXCR6/Bonzo.
The ED50, as measured by its ability to chemoattract mouse CXCR6-transfected mouse BaF3 cells, is less than 12ng/ml.
Lyophilized CXCL16 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution CXCL16 should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.