Cyantraniliprole (HGW-86)
(Synonyms: 溴氰虫酰胺; HGW-86) 目录号 : GC30177
An anthranilic diamide insecticide
Cas No.:736994-63-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Cyantraniliprole is an anthranilic diamide insecticide and an allosteric ryanodine receptor (RyR) activator.1 It induces calcium release from intracellular stores in Sf9 cells expressing H. virescens or D. melanogaster RyRs but not Sf9 cells that do not express RyRs. It is 300- to 500-fold selective for insect over mouse RyR1, greater than 2,000-fold selective for insect over rat RyR2, and inactive in human IMR32 cells expressing RyR2 and RyR3. It is active against insects of the order Lepidoptera, including the diamondback moth with a 50% plant protection value (PP50) of less than 0.1 ppm. It is also active against insects in the order Hemiptera, inducing mortality of the green peach aphid, cotton melon aphid, and white fly (EC50s = 1.1, 0.4, and 5.8 ppm, respectively). Formulations containing cyantraniliprole have been used as insecticides in greenhouse and nursery crops.
1.Lahm, G.P., Selby, T.P., Stevenson, T.M., et al.Pyrazolylpyridine activators of the insect ryanodine receptorBioactive heterocyclic compound classes: Agrochemicals251-263(2012)
| Cas No. | 736994-63-1 | SDF | |
| 别名 | 溴氰虫酰胺; HGW-86 | ||
| Canonical SMILES | O=C(C1=CC(Br)=NN1C2=NC=CC=C2Cl)NC3=C(C(NC)=O)C=C(C#N)C=C3C | ||
| 分子式 | C19H14BrClN6O2 | 分子量 | 473.71 |
| 溶解度 | DMSO : 50 mg/mL (105.55 mM);Water : < 0.1 mg/mL (insoluble) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.111 mL | 10.555 mL | 21.11 mL |
| 5 mM | 0.4222 mL | 2.111 mL | 4.222 mL |
| 10 mM | 0.2111 mL | 1.0555 mL | 2.111 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Uptake, translocation and distribution of Cyantraniliprole in rice planting system
J Hazard Mater 2022 Aug 15;436:129125.35739695 10.1016/j.jhazmat.2022.129125
While Cyantraniliprole has been frequently used in rice fields, knowledge of the uptake, translocation and distribution of Cyantraniliprole in rice planting systems is still largely unexplored. Plant uptake is a crucial factor in determining how Cyantraniliprole moves through the food chain. Understanding the uptake, translocation and distribution of Cyantraniliprole in rice planting system is essential to predicting its accumulation in rice and potential human exposure. Herein, the uptake process of Cyantraniliprole in a hydroponic-rice system was systematically investigated. Results showed that Cyantraniliprole was easily absorbed by rice roots via a passive diffusion process through the apoplastic pathway and then translocated upward through the xylem, but its acropetal translocation was limited. Cyantraniliprole in shoots can also be downward translocated through the phloem, although only to a limited extent, showing rice plants' weak phloem movement capacity. Furthermore, Cyantraniliprole had a short half-life in sediment-water system and dissipated faster in anaerobic than aerobic conditions. At the equilibrium stage of a sediment-water system, Cyantraniliprole is preferentially partitioned to the solid phase. Our study provides a systematic insight into the uptake, translocation and distribution of Cyantraniliprole in the rice planting system, which is very helpful for better field Cyantraniliprole application and environmental risk assessment.
Ryanodine Receptor as Insecticide Target
Curr Pharm Des 2022;28(1):26-35.34477510 10.2174/1381612827666210902150224
The ryanodine receptor (RyR) is one of the primary targets of commercial insecticides. The diamide insecticide family, including flubendiamide, chlorantraniliprole, Cyantraniliprole, etc., targets insect RyRs and can be used to control a wide range of destructive agricultural pests. The diamide insecticides are highly selective against lepidopteran and coleopteran pests with relatively low toxicity for non-target species, such as mammals, fishes, and beneficial insects. However, recently mutations identified on insect RyRs have emerged and caused resistance in several major agricultural pests throughout different continents. This review paper summarizes the recent findings on the structure and function of insect RyRs as insecticide targets. Specifically, we examine the structures of RyRs from target and non-target species, which reveals the molecular basis for insecticide action and selectivity. We also examine the structural and functional changes of RyR caused by the resistance mutations. Finally, we examine the progress in RyR structure-based insecticide design and discuss how this might help the development of a new generation of green insecticides.
Reduction in residual Cyantraniliprole levels in spinach after various washing and blanching methods
Front Nutr 2022 Jul 28;9:948671.35967805 PMC9370550
Pesticides are used to protect crops from pests and diseases. However, as many pesticides are toxic to humans, it is necessary to assess methods that can remove pesticide residues from agricultural products before human consumption. Spinach is consumed immediately after a relatively simple washing and heating process in the Republic of Korea. Cyantraniliprole is used as a systemic insecticide during spinach cultivation, which means it might remain in the crop after processing. Consequently, it is important to assess whether residues can be reduced to levels that are harmless to the human body after processing. This study investigated lowering the residual Cyantraniliprole levels in spinach after washing and blanching. The amount of Cyantraniliprole residue in the spinach samples sprayed with Cyantraniliprole during cultivation was analyzed using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The time of each washing and blanching method was set at 1, 3, and 5 min. The residual levels of Cyantraniliprole decreased by 15.1-54.6% and 60.1-93.5% based on the washing and blanching methods employed. The most effective washing method to lower residual Cyantraniliprole levels was steeping with a neutral detergent, resulting in Cyantraniliprole reduction by 42.9-54.6%. When spinach was blanched after steeping washing with a neutral detergent, the largest removal rates of 77.9 and 91.2% were observed after 1 and 3 min of blanching, respectively. Blanching for 5 min after steeping and running washing exhibited the highest reduction rate of 93.5%. Therefore, a considerable amount of Cyantraniliprole residue in spinach could be removed by washing or blanching. Based on the results of this study, blanching after steeping washing can be implemented as an effective method of lowering pesticide concentrations in spinach and other crops, thereby reducing their potential toxicity to humans upon consumption.
Residue and toxicity of Cyantraniliprole and its main metabolite J9Z38 in soil-earthworm microcosms
Chemosphere 2020 Jun;249:126479.32208218 10.1016/j.chemosphere.2020.126479
As part of a new generation of diamide insecticides, Cyantraniliprole has broad application prospects. In the present study, a QuEChERS-UPLC-MS/MS method was established to determine the residues of Cyantraniliprole and its main metabolite J9Z38 in soil and earthworms. Moreover, the accumulation and toxicity of Cyantraniliprole and J9Z38 in earthworms were evaluated. The present results show that the detection method of Cyantraniliprole and J9Z38 has high sensitivity and accuracy, which could be used for the accurate quantification of Cyantraniliprole and J9Z38 residues in soil and earthworms. Additionally, Cyantraniliprole degraded faster than its main metabolite J9Z38 in the artificial soil. Moreover, the bioenrichment efficiency of Cyantraniliprole was higher than J9Z38. The toxicity test result showed that Cyantraniliprole and J9Z38 could induce oxidative stress effect in earthworms from 5.0 mg/kg, finally resulting in cellular damage. Moreover, the oxidative damage degree induced by Cyantraniliprole was higher than J9Z38. Combining the results of residue test and toxicity test, although Cyantraniliprole degraded faster than its main metabolite J9Z38 in the artificial soil, its risk to earthworms was higher than J9Z38.
Persistence and metabolism of the diamide insecticide Cyantraniliprole in tomato plants
Sci Rep 2021 Nov 3;11(1):21570.34732779 PMC8566514
Plant uptake and metabolism of pesticides are complex and dynamic processes, which contribute to the overall toxicity of the pesticides. We investigated the metabolic fate of Cyantraniliprole, a new diamide class of insecticide, during various growth stages of tomato. Cyantraniliprole was the major residue in leaves, flowers, and fruits, with the relative metabolite-to-parent ratios maintained at < 10% up to 28 days after treatment (DAT). Mature leaves contained consistently higher residues of Cyantraniliprole than young leaves throughout the study. Flowers contained the highest Cyantraniliprole residues up to 21 DAT, then gradually decreased. Immature green fruits had the highest Cyantraniliprole residues (5.3 ± 0.7 ng/g; 42 DAT), and decreased toward red ripening stages (1.4 ± 0.2 ng/g; 84 DAT). Metabolism of Cyantraniliprole primarily occurred in the foliage, where 21 metabolites were tentatively identified. Flowers and fruits contained 14 and four of these metabolites, respectively. Major transformation pathways were characterized by ring closure, followed by N-demethylation, and glycosylation. Additionally, plant metabolism of Cyantraniliprole was also associated with several minor phase-I, phase-II, and breakdown metabolites. The occurrence of these metabolites in plants varied as a function of tissue types and their developmental stages. Our study highlights a tissue-specific biotransformation and accumulation of metabolites of Cyantraniliprole in tomato.