Cyclo(his-pro) (Cyclo(histidyl-proline))
(Synonyms: 环(组氨酰-脯氨酰),Cyclo(histidyl-proline); Histidylproline diketopiperazine) 目录号 : GC30806
A cyclic neuropeptide and metabolite of TRH
Cas No.:53109-32-3
Sample solution is provided at 25 µL, 10mM.
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Cyclo(L-His-L-Pro) is an endogenous cyclic neuropeptide and a metabolite of thyrotropin-releasing hormone (TRH).1 It is formed in the hypothalamus via the hydrolytic removal of pyroglutamic acid from TRH followed by non-enzymatic cyclization but is also synthesized de novo.2 It is ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood. Cyclo(L-His-L-Pro) (50 ?M) reduces LPS-induced production of reactive oxygen species (ROS) and nitric oxide (NO), as well translocation of NF-κB in BV-2 microglia. Levels of cyclo(L-His-L-Pro) are increased in rat brain after six weeks of continuous ethanol consumption and cyclo(L-His-L-Pro) reduces ethanol-induced sleep time in rats when administered at a dose of 1 ?mol/kg.1,3 Cyclo(L-His-L-Pro) induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice, effects that can be partially reversed by the opioid antagonist naloxone.1
1.Prasad, C.Neurobiology of cyclo(His-Pro)Ann. N. Y. Acad. Sci.553(1)232-251(1989) 2.Grottelli, S., Ferrari, I., Pietrini, G., et al.The role of cyclo(His-Pro) in neurodegenerationInt. J. Mol. Sci.17(8)1332(2016) 3.Prasad, C., Matsui, T., and Peterkofsky, A.Antagonism of ethanol narcosis by histidyl-proline diketopiperazineNature268(5616)142-144(1977)
| Cas No. | 53109-32-3 | SDF | |
| 别名 | 环(组氨酰-脯氨酰),Cyclo(histidyl-proline); Histidylproline diketopiperazine | ||
| Canonical SMILES | Cyclo(His-Pro) | ||
| 分子式 | C11H14N4O2 | 分子量 | 234.25 |
| 溶解度 | Water : ≥ 30 mg/mL (128.07 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.2689 mL | 21.3447 mL | 42.6894 mL |
| 5 mM | 0.8538 mL | 4.2689 mL | 8.5379 mL |
| 10 mM | 0.4269 mL | 2.1345 mL | 4.2689 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet