Cyclosporin C

Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties.1,2,3,4 It is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs = 0.1-5 μg/ml).2 Cyclosporin C (15 μg/ml) inhibits vaccinia virus replication in infected BSC40 cells by 98.82%.3 It inhibits lymphocyte proliferation induced by the mitogens concanavalin A , phytohemagglutinin L (PHA), and pokeweed mitogen (PWM), as well as proliferation induced by alloantigen in mixed lymphocyte culture when used at a concentration of 100 ng/ml.4 Cyclosporin C (100 ng/ml) inhibits the local graft versus host (GVH) reaction in mice receiving splenocyte grafts.

|1. von Wartburg, A., and Traber, R. Cyclosporins, fungal metabolites with immunosuppressive activities. Prog. Med. Chem. 25, 1-33 (1988).|2. Moussa•f, M., Jacques, P., Schaarw•chter, P., et al. Cyclosporin C is the main antifungal compound produced by Acremonium luzulae. Appl. Environ. Microbiol. 63(5), 1739-1743 (1997).|3. Damaso, C.R., and MoussatchÉ, N. Inhibition of vaccinia virus replication by cyclosporin A analogues correlates with their affinity for cellular cyclophilins. J. Gen. Virol. 79(Pt 2), 339-346 (1998).|4. Sadeg, N., Pham-Huy, C., Rucay, P., et al. In vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines A, C, D and metabolites M1, M17 and M21. Immunopharmacol. Immunotoxicol. 15(2-3), 163-177 (1993).