D-α-Tocopheryl Quinone

D-α-Tocopheryl quinone is an active oxidative metabolite of vitamin E and an essential cofactor for mitochondrial fatty acid desaturases.¹ It has antioxidant activity in oxygen radical absorbance capacity (ORAC) and radical trapping assays when used at a concentration of 25 µM and inhibits ferroptosis induced by (1S,3R)-RSL3 in Q7 cells (EC₅₀ = 0.233 µM).² D-α-Tocopheryl quinone (20 mg/kg) decreases serum malondialdehyde (MDA) and blood glucose levels and restores the number and diversity of intestinal microflora in a rat model of high cholesterol and cholate diet-induced non-alcoholic steatohepatitis (NASH).³

1.Infante, J.P.A function for the vitamin E metabolite alpha-tocopherol quinone as an essential enzyme cofactor for the mitochondrial fatty acid desaturasesFEBS Lett.446(1)1-5(1999) 2.Hinman, A., Holst, C.R., Latham, J.C., et al.Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.PLoS One13(8)e0201369(2018) 3.Sun, T., Zhang, B., Ru, Q.-J., et al.Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in ratsPharm. Biol.59(1)723-731(2021)