D-Erythrose 4-phosphate sodium
(Synonyms: D-赤藓糖 4-磷酸钠) 目录号 : GC60756
D-Erythrose 4-phosphate sodium是单糖赤藓糖的磷酸钠盐，是磷酸戊糖途径和卡尔文循环的中间体。D-Erythrose 4-phosphate sodium能够用作底物，用于识别、区分和表征微生物和植物中启动莽草酸途径的各种合成酶。
Cas No.:103302-15-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >91.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
D-Erythrose 4-phosphate sodium is the sodium phosphate salt of the monosaccharide erythrose, an intermediate in the pentose phosphate pathway and the Calvin cycle[1]. D-Erythrose 4-phosphate sodium can be used as a substrate to identify, differentiate and characterize various synthases that initiate the shikimate pathway in microorganisms and plants[2]. D-Erythrose 4-phosphate sodium can be used to identify, differentiate and characterize 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) aldolase[3]. Erythritol is converted to D-Erythrose 4-phosphate sodium through a series of reactions involving three isomerases that are homologous to the metal-dependent xylose isomerase-like superfamily, triose-P isomerase and ribose-P isomerase, respectively[4]. D-Erythrose 4-phosphate sodium can be used to measure the concentration of ribulose-5-phosphate (Ru-5-P) in cells[5]. D-Erythrose 4-phosphate sodium is a phosphoenolpyruvate analog and an inhibitor of chorionic villus mutase[6].
References:
[1] Robyt J F. General Occurrence of Carbohydrates[J]. Glycoscience: Chemistry and Chemical Biology I–III, 2001: 75-114.
[2] Ran N, Draths K M, Frost J W. Creation of a shikimate pathway variant[J]. Journal of the American Chemical Society, 2004, 126(22): 6856-6857.
[3] Ran N, Frost J W. Directed evolution of 2-keto-3-deoxy-6-phosphogalactonate aldolase to replace 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase[J]. Journal of the American Chemical Society, 2007, 129(19): 6130-6139.
[4] Barbier T, Collard F, Zúñiga-Ripa A, et al. Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella[J]. Proceedings of the National Academy of Sciences, 2014, 111(50): 17815-17820.
[5] Liu R, Li W, Tao B, et al. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance[J]. Nature communications, 2019, 10(1): 991.
[6] Almeida A M, Marchiosi R, Abrahão J, et al. Revisiting the shikimate pathway and highlighting their enzyme inhibitors[J]. Phytochemistry Reviews, 2024, 23(2): 421-457.
D-Erythrose 4-phosphate sodium是单糖赤藓糖的磷酸钠盐，是磷酸戊糖途径和卡尔文循环的中间体[1]。D-Erythrose 4-phosphate sodium能够用作底物，用于识别、区分和表征微生物和植物中启动莽草酸途径的各种合成酶[2]。D-Erythrose 4-phosphate sodium能够用作鉴定、区分和表征2-酮-3-脱氧-6-磷酸半乳糖酸（KDPGal）醛缩酶[3]。赤藓糖醇通过一系列反应转化为D-Erythrose 4-phosphate sodium，这些反应涉及三种异构酶，这三种异构酶分别与金属依赖性木糖异构酶样超家族、丙糖-P异构酶和核糖-P异构酶同源[4]。D-Erythrose 4-phosphate sodium可用于细胞内核酮糖-5-磷酸（Ru-5-P）的浓度测量[5]。D-Erythrose 4-phosphate sodium是一种磷酸烯醇式丙酮酸类似物和绒毛膜酸变位酶的抑制剂[6]。
| Cas No. | 103302-15-4 | SDF | |
| 别名 | D-赤藓糖 4-磷酸钠 | ||
| Canonical SMILES | O=C[C@H](O)[C@H](O)COP(O)(O[Na])=O | ||
| 分子式 | C4H8NaO7P | 分子量 | 222.07 |
| 溶解度 | H2O : 50 mg/mL (225.15 mM; Need ultrasonic and warming) | 储存条件 | -20°C, stored under nitrogen, away from moisture |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.5031 mL | 22.5154 mL | 45.0308 mL |
| 5 mM | 0.9006 mL | 4.5031 mL | 9.0062 mL |
| 10 mM | 0.4503 mL | 2.2515 mL | 4.5031 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。