D-Galactose (D-(+)-Galactose)
(Synonyms: D-半乳糖; D-(+)-Galactose) 目录号 : GC30795
A natural aldohexose
Cas No.:59-23-4
Sample solution is provided at 25 µL, 10mM.
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D-Galactose is a natural aldohexose and C-4 epimer of glucose. D-galactose is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. Chronic, systemic exposure to D-galactose accelerates senescence in invertebrates and mammals and has been used as a model for aging.1 In bacteria, D-galactose is imported by a methyl-galactoside transport system to drive chemotaxis.2
D-半乳糖是一种天然的醛糖，也是葡萄糖的C-4异构体。D-半乳糖可以通过酶促反应转化为D-葡萄糖进行代谢或用于多糖的储存。长期、全身性的接触D-半乳糖会加速无脊椎动物和哺乳动物的衰老，因此被用作衰老的模型。[1]在细菌中，D-半乳糖通过甲基半乳糖运输系统进入细胞，驱动趋化。2
1.Cui, X., Zuo, P., Zhang, Q., et al.Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: Protective effects of R-α-lipoic acidJ. Neurosci. Res.84(3)647-654(2006) 2.Borrok, M.J., Kiessling, L.L., and Forest, K.T.Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structuresProtein Sci.16(6)1032-1041(2007)
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Animal experiment: |
Rats: D-galactose is dissolved in water for administration at the dose of 100 mg/kg of body weight, and given by oral gavage, once a day, over a period of 1, 2, 4, 6 or 8 weeks. Animals are randomized into two groups: control animals (receiving water by oral gavage) or d-gal animals (receiving D-galactose by oral gavage). The behavioral tests and biochemical analysis are undertaken on the1st, 2nd, 4th, 6th and 8th weeks after the last administration of d-gal[3]. Mice: Male adult C57BL/6 mice are randomly divided into three groups (control, D-galactose, and D-galactose plus α-LA). D-galactose (100 mg/kg) is injected subcutaneously (s.c.) daily into mice for 7 weeks. α-LA (100 mg/kg body weight) is injected peritoneally (i.p.) daily concomitantly for 7 weeks. All control animals are given saline[2]. |
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References: [1]. Csiszovszki Z, et al. Structure and function of the D-galactose network in enterobacteria. MBio. 2011 Jun 28;2(4):e00053-11. |
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| Cas No. | 59-23-4 | SDF | |
| 别名 | D-半乳糖; D-(+)-Galactose | ||
| Canonical SMILES | O=C[C@@H]([C@H]([C@H]([C@@H](CO)O)O)O)O | ||
| 分子式 | C6H12O6 | 分子量 | 180.16 |
| 溶解度 | Water : ≥ 100 mg/mL (555.06 mM) | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.5506 mL | 27.7531 mL | 55.5062 mL |
| 5 mM | 1.1101 mL | 5.5506 mL | 11.1012 mL |
| 10 mM | 0.5551 mL | 2.7753 mL | 5.5506 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet