D-Glucose-6-phosphate (sodium salt)
(Synonyms: D-葡萄糖-6-磷酸) 目录号 : GC43434
D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步。
Cas No.:54010-71-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
D-Glucose-6-phosphate (sodium salt) is an essential component of glucose metabolism. It is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or glucose-1-phosphate is converted by phosphoglucomutase, which is the first step in glycogen synthesis [1]. D-Glucose 6-Phosphate is located at the starting point of two major metabolic pathways: glycolysis and the pentose phosphate pathway [2]. D-Glucose 6-Phosphate can be converted to glycogen or starch and stored in cells [3]. D-Glucose 6-Phosphate can be used as a substrate to measure the activity of recombinant mannitol-1-phosphatase (M1Pase) [4]. D-Glucose 6-Phosphate can be used as a substrate to measure the specificity of SapM protein [5]. This product is the sodium salt form of D-Glucose 6-Phosphate, with a molecular formula of C6H12NaO9P and a molecular weight of 282.12.
References:
[1]Jang W, Gomer R H. Exposure of cells to a cell number-counting factor decreases the activity of glucose-6-phosphatase to decrease intracellular glucose levels in Dictyostelium discoideum[J]. Eukaryotic cell, 2005, 4(1): 72-81.
[2]Litwack, Gerald .Chapter 6-Insulin and Sugars.Human Biochemistry. Academic Press.2018:131–160.
[3]Lal M A. Metabolism of storage carbohydrates[J]. Plant physiology, development and metabolism. Springer Nature, Singapore. Doi, 2018, 10: 978-981.
[4] Groisillier A, Tonon T. Determination of Recombinant Mannitol-1-phosphatase Activity from Ectocarpus sp[J]. Bio-protocol, 2016, 6(16): e1896-e1896.
[5]Fernandez-Soto P, Bruce A J E, Fielding A J, et al. Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs[J]. Scientific reports, 2019, 9(1): 10315.
D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步[1]。D-Glucose 6-Phosphate位于两个主要代谢途径的起点：糖酵解和磷酸戊糖途径[2]。D-Glucose 6-Phosphate可以转化为糖原或淀粉储存在细胞中[3]。D-Glucose 6-Phosphate可作为底物用于测定重组甘露醇-1-磷酸酶（M1Pase）活性[4]。D-Glucose 6-Phosphate可作为底物用于测定SapM蛋白的特异性[5]。本产品是D-Glucose 6-Phosphate的钠盐形式，分子式为C6H12NaO9P，分子量为282.12。
| Cas No. | 54010-71-8 | SDF | |
| 别名 | D-葡萄糖-6-磷酸 | ||
| 化学名 | sodium ((2R,3S,4S,5R,6R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl hydrogenphosphate | ||
| Canonical SMILES | O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)COP(O)([O-])=O.[Na+] | ||
| 分子式 | C6H12NaO9P | 分子量 | 282.12 |
| 溶解度 | 10mg in PBS， pH 7.2 | 储存条件 | Store at 2-8°C; sealed storage, away from moisture |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5446 mL | 17.723 mL | 35.4459 mL |
| 5 mM | 0.7089 mL | 3.5446 mL | 7.0892 mL |
| 10 mM | 0.3545 mL | 1.7723 mL | 3.5446 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
One-step preparation of carbonaceous spheres rich in phosphate groups via hydrothermal carbonization for effective phosphopeptides enrichment
J Chromatogr A 2021 Aug 16;1651:462285.PMID:34090058DOI:10.1016/j.chroma.2021.462285.
A green strategy was developed to prepare carbonaceous spheres rich in phosphoric acid groups on the surface with D-Glucose 6-phosphate sodium salt (called G6PNa2) as a sole carbon source through one-step hydrothermal carbonization method. The method is simple and facile and meets the standards of green chemistry as water is the sole solvent employed. Following the hydrothermal carbonization synthesis, the carbonaceous spheres were further functionalized with Ti4+. The main factors including reaction temperature, reaction time, and concentration of G6PNa2 were systematically studied in order to obtain the desirable morphology and the optimum phosphopeptides enrichment, for the resulting Ti4+ functionalized carbonaceous spheres (CS-Ti4+). The performance evaluation of the CS-Ti4+ prepared under the optimum conditions demonstrated excellent selectivity (1:1000), low detection limit (1 fmol) and high recovery rate (85%) towards phosphopeptides. Furthermore, 24 low-abundance phosphopeptides were captured from human saliva using CS-Ti4+, indicating its great potential in mass spectrometry-based phosphoproteome studies.
Insights into the conversion of dissolved organic phosphorus favors algal bloom, arsenate biotransformation and microcystins release of Microcystis aeruginosa
J Environ Sci (China) 2023 Mar;125:205-214.PMID:36375906DOI:10.1016/j.jes.2021.11.025.
Little information is available on influences of the conversion of dissolved organic phosphorus (DOP) to inorganic phosphorus (IP) on algal growth and subsequent behaviors of arsenate (As(V)) in Microcystis aeruginosa (M. aeruginosa). In this study, the influences factors on the conversion of three typical DOP types including adenosine-5-triphosphate disodium salt (ATP), β-glycerophosphate sodium (βP) and D-Glucose-6-phosphate disodium salt (GP) were investigated under different extracellular polymeric secretions (EPS) ratios from M. aeruginosa, and As(V) levels. Thus, algal growth, As(V) biotransformation and microcystins (MCs) release of M. aeruginosa were explored in the different converted DOP conditions compared with IP. Results showed that the three DOP to IP without EPS addition became in favor of algal growth during their conversion. Compared with IP, M. aeruginosa growth was thus facilitated in the three converted DOP conditions, subsequently resulting in potential algal bloom particularly at arsenic (As) contaminated water environment. Additionally, DOP after conversion could inhibit As accumulation in M. aeruginosa, thus intracellular As accumulation was lower in the converted DOP conditions than that in IP condition. As(V) biotransformation and MCs release in M. aeruginosa was impacted by different converted DOP with their different types. Specifically, DMA concentrations in media and As(III) ratios in algal cells were promoted in converted βP condition, indicating that the observed dissolved organic compositions from βP conversion could enhance As(V) reduction in M. aeruginosa and then accelerate DMA release. The obtained findings can provide better understanding of cyanobacteria blooms and As biotransformation in different DOP as the main phosphorus source.