D-Glucose-6-phosphate (sodium salt)
(Synonyms: D-葡萄糖-6-磷酸) 目录号 : GC43434
D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步。
Cas No.:54010-71-8
Sample solution is provided at 25 µL, 10mM.
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D-Glucose-6-phosphate (sodium salt) is an essential component of glucose metabolism. It is formed in cells when glucose is phosphorylated by hexokinase (or glucokinase) or glucose-1-phosphate is converted by phosphoglucomutase, which is the first step in glycogen synthesis [1]. D-Glucose 6-Phosphate is located at the starting point of two major metabolic pathways: glycolysis and the pentose phosphate pathway [2]. D-Glucose 6-Phosphate can be converted to glycogen or starch and stored in cells [3]. D-Glucose 6-Phosphate can be used as a substrate to measure the activity of recombinant mannitol-1-phosphatase (M1Pase) [4]. D-Glucose 6-Phosphate can be used as a substrate to measure the specificity of SapM protein [5]. This product is the sodium salt form of D-Glucose 6-Phosphate, with a molecular formula of C6H12NaO9P and a molecular weight of 282.12.
References:
[1]Jang W, Gomer R H. Exposure of cells to a cell number-counting factor decreases the activity of glucose-6-phosphatase to decrease intracellular glucose levels in Dictyostelium discoideum[J]. Eukaryotic cell, 2005, 4(1): 72-81.
[2]Litwack, Gerald .Chapter 6-Insulin and Sugars.Human Biochemistry. Academic Press.2018:131–160.
[3]Lal M A. Metabolism of storage carbohydrates[J]. Plant physiology, development and metabolism. Springer Nature, Singapore. Doi, 2018, 10: 978-981.
[4] Groisillier A, Tonon T. Determination of Recombinant Mannitol-1-phosphatase Activity from Ectocarpus sp[J]. Bio-protocol, 2016, 6(16): e1896-e1896.
[5]Fernandez-Soto P, Bruce A J E, Fielding A J, et al. Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs[J]. Scientific reports, 2019, 9(1): 10315.
D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步[1]。D-Glucose 6-Phosphate位于两个主要代谢途径的起点：糖酵解和磷酸戊糖途径[2]。D-Glucose 6-Phosphate可以转化为糖原或淀粉储存在细胞中[3]。D-Glucose 6-Phosphate可作为底物用于测定重组甘露醇-1-磷酸酶（M1Pase）活性[4]。D-Glucose 6-Phosphate可作为底物用于测定SapM蛋白的特异性[5]。本产品是D-Glucose 6-Phosphate的钠盐形式，分子式为C6H12NaO9P，分子量为282.12。
| Cas No. | 54010-71-8 | SDF | |
| 别名 | D-葡萄糖-6-磷酸 | ||
| 化学名 | sodium ((2R,3S,4S,5R,6R)-3,4,5,6-tetrahydroxytetrahydro-2H-pyran-2-yl)methyl hydrogenphosphate | ||
| Canonical SMILES | O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)COP(O)([O-])=O.[Na+] | ||
| 分子式 | C6H12NaO9P | 分子量 | 282.12 |
| 溶解度 | 10mg in PBS， pH 7.2 | 储存条件 | Store at 2-8°C; sealed storage, away from moisture |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5446 mL | 17.723 mL | 35.4459 mL |
| 5 mM | 0.7089 mL | 3.5446 mL | 7.0892 mL |
| 10 mM | 0.3545 mL | 1.7723 mL | 3.5446 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet