Home>>Natural Products>>D-Tetramannuronic acid

D-Tetramannuronic acid Sale

(Synonyms: D-甘露糖醛酸四糖) 目录号 : GC60795

D-Tetramannuronicacid是一种藻酸盐低聚物,是由海洋褐藻和某些革兰氏阴性细菌产生的。D-Tetramannuronicacid可用于疼痛和血管性痴呆的研究。

D-Tetramannuronic acid Chemical Structure

Cas No.:149511-34-2

规格 价格 库存 购买数量
5mg
¥2,250.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

D-Tetramannuronic acid, an alginate oligomer, is produced by marine brown algae and by a limited range of Gram negative bacteria. D-Tetramannuronic acid can be used for the research of pain and vascular dementia[1][2][3][4].

[1]. Heyraud A, et, al. HPLC analysis of saturated or unsaturated oligoguluronates and oligomannuronates. Application to the determination of the action pattern of Haliotis tuberculata alginate lyase. Carbohydr Res. 1996 Sep 23; 291:115-26. [2]. Iwamoto M, et, al. Structure-activity relationship of alginate oligosaccharides in the induction of cytokine production from RAW264.7 cells. FEBS Lett. 2005 Aug 15; 579(20): 4423-9. [3]. Geng M, et, al. Application of sodium alginate oligose and derivative to treatment of pain. CN106344595A. [4]. Geng M, et, al. Application of sodium alginate oligose and derivative to treatment of vascular dementia. CN106344593A.

Chemical Properties

Cas No. 149511-34-2 SDF
别名 D-甘露糖醛酸四糖
Canonical SMILES OC([C@@H](O[C@H]1O[C@@H]([C@@H]([C@@H]2O)O)[C@H](O[C@H]2O)C(O)=O)[C@H]([C@@H]([C@@H]1O)O)O[C@@H]([C@H]([C@H]3O)O)O[C@@H]([C@H]3O[C@@H]([C@H]([C@H]4O)O)O[C@@H]([C@H]4O)C(O)=O)C(O)=O)=O
分子式 C24H34O25 分子量 722.51
溶解度 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.3841 mL 6.9203 mL 13.8406 mL
5 mM 0.2768 mL 1.3841 mL 2.7681 mL
10 mM 0.1384 mL 0.692 mL 1.3841 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置

Research Update

Protective effect of D-Tetramannuronic acid tetrasodium salt on UVA-induced photo-aging in HaCaT cells

Biomed Pharmacother 2020 Jun;126:110094.PMID:32200257DOI:10.1016/j.biopha.2020.110094

UVA radiation from the sun is the main external stimulus in the pathogenesis of skin photo-aging. This process is associated with cellular oxidative stress. Here we aim at showing the protective effect of D-Tetramannuronic acid Tetrasodium Salt (M4), a natural product, against UVA (30J/cm2) irradiation-induced oxidative stress and photo-aging in HaCaT cells, and to reveal the molecular mechanism underlying the protective efficacy. M4 pretreatment significantly increased HaCaT cell viability and MMP, suppressing UVA-induced ROS generation. Moreover, M4 treatment prevented the UVA-induced photo-aging of HaCaT cells (the reduction of cell viability, mitochondria dysfunction, and SIRT1/pGC-1α deregulation). Notably, the anti-photo-aging potential of M4 was directly associated with the increased expression of MMP and SIRT1, which was followed by the up-regulation of pGC-1α, D-LOOP, and Mt-TFA, and the transcriptional activation of NRF1/NRF2. Therefore, M4 is useful for the protection of skin cells from UVA-induced photo-aging.