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Dacarbazine Sale

(Synonyms: 达卡巴嗪; Imidazole Carboxamide) 目录号 : GC14485

A DNA alkylating prodrug

Dacarbazine Chemical Structure

Cas No.:4342-03-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥399.00
现货
200mg
¥410.00
现货
1g
¥788.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Dacarbazine, an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. Dacarbazine is also a member of the class of alkylating agents, which destroy cancer cells by adding an alkyl group (CnH2n+1) to its DNA.[1] The alkyl group is attached to the guanine base of DNA, at the number 7 nitrogen atom of the purine ring.Cancer cells are more sensitive to DNA damage than normal cells, because its proliferate faster and with less error-correcting than healthy cells, but alkylating antineoplastic agent are also toxic to normal cells (cytotoxic), leading to damage, in particular in cells that divide frequently, as those in the gastrointestinal tract, bone marrow, testicles and ovaries.[2]
Dacarbazine is commonly used as a single agent in the treatment of metastatic melanoma in middle of 2006, and as part of the ABVD chemotherapy regimen to treat Hodgkin lymphoma, and in the MAID regimen for sarcoma.Currently, Dacarbazine combined with Oblimersen for the treatment of malignant melanoma in clinical trials.[3]Dacarbazine is normally administered by injection (a shot) or intravenous infusion (IV) under the immediate supervision of a doctor or nurse.Now in phase III about Melanoma Recurrent 2015 March.
References:1. "Alkylating Agents". US National Library of Medicine. Retrieved 2 August 2014.
2. Wiedemann GJ. et al. "Ifosfamide, carboplatin and etoposide (ICE) combined with 41.8 degrees C whole body hyperthermia in patients with refractory sarcoma". European Journal of Cancer 1996,32A (5): 888–92.
3. MedLine, U.S. National Institutes of Health, National Library of Medicine.
4. CClinicalTrials.gov Identifier:NCT02288897.

Chemical Properties

Cas No. 4342-03-4 SDF
别名 达卡巴嗪; Imidazole Carboxamide
化学名 (5E)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide
Canonical SMILES CN(C)NN=C1C(=NC=N1)C(=O)N
分子式 C6H10N6O 分子量 182.18
溶解度 ≥ 2.3mg/mL in DMSO, ≥ 0.54 mg/mL in Water, <0.49 mg/mL in EtOH 储存条件 4°C, protect from light
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.4891 mL 27.4454 mL 54.8908 mL
5 mM 1.0978 mL 5.4891 mL 10.9782 mL
10 mM 0.5489 mL 2.7445 mL 5.4891 mL
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