Darodipine (PY 108-068)
(Synonyms: 达罗地平,PY 108-068; PY-108068) 目录号 : GC31301
Darodipine (PY 108-068) (PY 108-068, PY-108068) 是一种有效的钙通道拮抗剂。
Cas No.:72803-02-2
Sample solution is provided at 25 µL, 10mM.
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Darodipine (PY 108-068, PY-108068) is a potent calcium channel antagonist.
Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon's horn is the most sensitive to treatment with darodipine[1]. Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10 mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex[2].
[1]. Amenta F, et al. Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine(PY 108-068) on the cerebral capillary network in aged rats. Mech Ageing Dev. 1995 Jan 31;78(1):27-37. [2]. Vega JA, et al. Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of neurofilament protein immunoreactivity in the cerebellar cortex of aged rats. Mech Ageing Dev. 1994 Aug;75(2):169-77.
Animal experiment: | Rats: Male Wistar rats are used. Twelve-month-old rats are left untreated and used as adult reference animals. Twenty-one-month-old rats are allotted randomly to two groups of 8 animals each. Rats of the first group receive an oral daily dose of 5 mg/kg of darodipine in drinking water. The animals of the second group are left untreated and served as a control group. Rats of these two groups are allowed to survive for 6 months, until 27 months of age (old rats). Darodipine-treated rats have water consumption determined every second day and body weight determined weekly[1]. |
References: [1]. Amenta F, et al. Effect of long-term treatment with the dihydropyridine-type calcium channel blocker darodipine(PY 108-068) on the cerebral capillary network in aged rats. Mech Ageing Dev. 1995 Jan 31;78(1):27-37. | |
| Cas No. | 72803-02-2 | SDF | |
| 别名 | 达罗地平,PY 108-068; PY-108068 | ||
| Canonical SMILES | O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C2=CC=CC3=NON=C32)OCC | ||
| 分子式 | C19H21N3O5 | 分子量 | 371.39 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6926 mL | 13.4629 mL | 26.9259 mL |
| 5 mM | 0.5385 mL | 2.6926 mL | 5.3852 mL |
| 10 mM | 0.2693 mL | 1.3463 mL | 2.6926 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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