DCXR Human, Bioactive
目录号 : GP21547Dicarbonyl/L-Xylulose Reductase Human Recombinant, Bioactive
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | DCR; HCR2; HCRII; KIDCR; P34H; SDR20C1; Dicarbonyl/L-Xylulose Reductase; EC=1.1.1.10; Carbonyl reductase II; Kidney dicarbonyl reductase; Sperm surface protein P34H. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Biological Activity | Specific activity is > 1,800 pmol/min/ug and isdefined as the amount of enzyme that oxidize 1pmole of xylitol to L-xyluloseper minute at pH 10.0 at 37C. | ||
| Formulation | The DCXR (0.5mg/ml) solution containing 20mM Tris-HClbuffer (pH 8.0), 1mM DTT, 20% glycerol and 50mM NaCl. | ||
DCXR catalyzes the NADPH-dependent reduction of numerous pentoses, tetroses, trioses, alpha-dicarbonyl molecules and L-xylulose. DCXR takes part in the uronate cycle of glucose metabolism. DCXR participates in the water absorption andcellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thus preventing osmolytic stress from occurring in the renal tubules.
Specific activity is > 1,800 pmol/min/ug and isdefined as the amount of enzyme that oxidize 1pmole of xylitol to L-xyluloseper minute at pH 10.0 at 37C.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.