Decursin ((+)-Decursin)

Decursin is a phytochemical originally isolated from A. gigas with diverse biological activities.^1,2,3,4,5 It reduces the growth of B16/F10 murine melanoma cells, but not NIH-3T3 fibroblasts, via induction of apoptosis and increased caspase-3 activity when used at concentrations ranging from 40 to 100 μM.¹ In vivo, decursin (10 mg/kg, i.p.) reduces tumor growth in a B16/F10 mouse xenograft model. Decursin inhibits RANKL-induced osteoclast differentiation and decreases fusion and migrations of pre-osteoclasts in vitro and prevents LPS-induced bone erosion in mice.² In a mouse model of seizures induced by kainic acid , decursin (20 mg/kg) increases latency to the first electroencephalographic (EEG) discharge and attenuates the intensity and reduces the frequency of seizure discharges in the parietal cortex.³ Decursin inhibits tube formation and expression of VEGF receptor 2 (VEGFR2) in human retinal microvascular endothelial cells (HRMECs) and human umbilical vein endothelial cells (HUVECs) in vitro and reduces retinal expression of VEGFR2 and neovascularization in rats with diabetes induced by streptozotocin .⁴ It also reduces hepatic collagen expression, serum levels of ALT, AST, and ALP, and production of reactive oxygen species (ROS) in a mouse model of CCL₄-induced liver fibrosis.⁵

1.Kim, B.S., Seo, H., Kim, H.-J., et al.Decursin from Angelica gigas nakai inhibits B16F10 melanoma growth through induction of apoptosisJ. Med. Food.18(10)1121-1127(2015) 2.Kim, K.-J., Yeon, J.-T., Choi, S.-W., et al.Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclastsBone81208-216(2015) 3.Lee, J.-K., Jeong, J.W., Jang, T., et al.Decursin attenuates kainic acid-induced seizures in miceNeuroreport25(16)1243-1249(2014) 4.Yang, Y., Yang, K., Li, Y., et al.Decursin inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2Mol. Cell. Endocrinol.378(1-2)46-52(2013) 5.Choi, Y.J., Kim, D.H., Kim, S.J., et al.Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitroLife Sci.108(2)94-103(2014)