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Deferiprone-d3 Sale

(Synonyms: 去铁酮 d3) 目录号 : GC45765

An internal standard for the quantification of deferiprone

Deferiprone-d3 Chemical Structure

Cas No.:1346601-82-8

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1mg
¥1,713.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Deferiprone-d3 is intended for use as an internal standard for the quantification of deferiprone by GC- or LC-MS. Deferiprone is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio and has antioxidant and neuroprotective activities.1 It reduces levels of intracellular iron and inhibits lipid peroxidation in primary rat hepatocytes when used at concentrations of 200 and 50 μM, respectively.2 Deferiprone reduces cholesterol diet-induced increases in the levels of amyloid-β (1-42) (Aβ42), Aβ40, and the phosphorylation of tau and glycogen synthase kinase 3β (GSK3β) in the rabbit hippocampus when administered at a dose of 50 mg/kg.3 Formulations containing deferiprone have been used in the treatment of thalassemia.

|1. BarnabÉ, N., Zastre, J.A., Venkataram, S., et al. Deferiprone protects against doxorubicin-induced myocyte cytotoxicity. Free Radic. Biol. Med. 33(2), 266-275 (2002).|2. Morel, I., Cillard, J., Lescoat, G., et al. Antioxidant and free radical scavenging activities of the iron chelators pyoverdin and hydroxypyrid-4-ones in iron-loaded hepatocyte cultures: Comparison of their mechanism of protection with that of desferrioxamine. Free Radic. Biol. Med. 13(5), 499-508 (1992).|3. Prasanthi, J.R., Schrag, M., Dasari, B., et al. Deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. J. Alzheimers Dis. 30(1), 167-182 (2012).

Chemical Properties

Cas No. 1346601-82-8 SDF
别名 去铁酮 d3
Canonical SMILES O=C1C(O)=C(C)N(C([2H])([2H])[2H])C=C1
分子式 C7H6D3NO2 分子量 142.2
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mM 7.0323 mL 35.1617 mL 70.3235 mL
5 mM 1.4065 mL 7.0323 mL 14.0647 mL
10 mM 0.7032 mL 3.5162 mL 7.0323 mL
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