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Delapril hydrochloride Sale

(Synonyms: 地拉普利盐酸盐) 目录号 : GC38766

Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

Delapril hydrochloride Chemical Structure

Cas No.:83435-67-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥405.00
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5mg
¥360.00
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10mg
¥630.00
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25mg
¥1,260.00
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50mg
¥1,620.00
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100mg
¥2,160.00
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Sample solution is provided at 25 µL, 10mM.

Description

Delapril Hydrochloride (Alindapril) is the hydrochloride salt form of delapril, which is a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

The poteny of delapril is about 15 times greater than captopril and almost equal to enalaprilat in inhibiting rabbit lung ACE activity in vitro and about 10 times greater than captopril in inhibiting angiotensin I-induced contraction in isolated tissue preparations, such as rat aortic rings and rat kidney[2].

After oral administration of [14C]delapril 10 mg/kg to rats, 57% of the dose is absorbed mainly in the small intestine via the portal route and extensively metabolized by esterases to the diacid derivative M-I. Plasma levels of M-I peak within 0.4 hour of administration (maximum concentration [Cmax] 1.23 μg/mL), then decline biphasically with half-lives of 0.6 and 9.1 hours. In dogs given 10 mg/kg of [14C]delapril, 72% of the dose is absorbed. Plasma levels of M-I peak within 0.4 hour of administration (Cmax, 0.9 μg/ mL), then decline biphasically with half-lives of 0.3 and 2.8 hours. Delapril is able to inhibit plasma and tissue ACE at doses 5-10 times lower than captopril and this has also been found in in vivo experiments. Delapril has been shown to decrease heart weight, left ventricular weight, the wall to lumen ratio of small coronary arterioles, and thickness of the left ventricular wall in stroke-prone SHR, to reduce cardiac renin gene expression in SHR, and to protect perfused rat hearts against ischemia-reperfusion injury[2].

[1] Saruta T, et al. Am J Hypertens. 1991, 4(1 Pt 2):23S-28S. [2] Razzetti R, et al. Am J Cardiol. 1995, 75(18):7F-12F.

化学性质

Cas No. 83435-67-0 SDF
别名 地拉普利盐酸盐
Canonical SMILES CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N(C2CC3=C(C=CC=C3)C2)CC(O)=O)=O)=O.[H]Cl
分子式 C26H33ClN2O5 分子量 489
溶解度 DMSO: 250 mg/mL (511.25 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.045 mL 10.2249 mL 20.4499 mL
5 mM 0.409 mL 2.045 mL 4.09 mL
10 mM 0.2045 mL 1.0225 mL 2.045 mL
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