Dendrophenol
(Synonyms: 石斛酚; Moscatilin) 目录号 : GC34556Dendrophenol (Moscatilin) is from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. Dendrophenol (Moscatilin) almost completely suppresses (97%) the AFB1-induced SOS response with an IC50 of 0.08 μM.
Cas No.:108853-14-1
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >98.00%
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Dendrophenol (Moscatilin) is from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. Dendrophenol (Moscatilin) almost completely suppresses (97%) the AFB1-induced SOS response with an IC50 of 0.08 μM.
Dendrophenol induces apoptosis of colorectal HCT-116 cells via tubulin depolymerization and DNA damage stress and that this leads to the activation of JNK and mitochondria-involved intrinsic apoptosis pathway.[2]
In Male severe combined immunodeficient mice implanted with HCT-116 cells, the i.p. treatment with dendrophenol causes a significant inhibition of tumor growth without the loss of body weight.[2]
[1] Miyazawa M, et al. J Agric Food Chem. 1999 May;47(5):2163-7. [2] Chen TH, et al. Clin Cancer Res. 2008 Jul 1;14(13):4250-8.
Cas No. | 108853-14-1 | SDF | |
别名 | 石斛酚; Moscatilin | ||
Canonical SMILES | COC1=C(O)C=CC(CCC2=CC(OC)=C(O)C(OC)=C2)=C1 | ||
分子式 | C17H20O5 | 分子量 | 304.34 |
溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 3.2858 mL | 16.429 mL | 32.858 mL |
5 mM | 0.6572 mL | 3.2858 mL | 6.5716 mL |
10 mM | 0.3286 mL | 1.6429 mL | 3.2858 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
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