Desipramine-d4 (hydrochloride)
(Synonyms: 盐酸去郁敏D4) 目录号 : GC49858
An internal standard for the quantification of desipramine
Cas No.:61361-34-0
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Desipramine-d4 is intended for use as an internal standard for the quantification of desipramine by GC- or LC-MS. Desipramine is a tricyclic antidepressant and an active metabolite of imipramine .1 It inhibits the serotonin (5-HT) and norepinephrine transporters (Kis = 163 and 3.5 nM for human SERT and NET, respectively) and is an antagonist of the 5-HT receptor subtype 5-HT2A and the α1-adrenergic receptor (α1-AR), as well as histamine H1 and muscarinic acetylcholine receptors (mAChRs; Kis = 115, 23, 31, and 37 nM, respectively). Desipramine is selective for the 5-HT2A receptor over the 5-HT1A receptor (Ki = 2,272 nM) and for α1-AR over α2-AR (Ki = 1,379 nM). It also selectively inhibits G protein-activated inward rectifier potassium channel (GIRK), also known as Kir3, currents in Xenopus oocytes expressing human GIRK1 and GIRK2 or human GIRK1 and GIRK4 (IC50s = 36.4 and 53.9 µM, respectively) over Kir1.1 or Kir2.1 currents in Xenopus oocytes expressing the human channels (IC50s = >100 µM for both).2 Desipramine (3.2 mg/kg) decreases immobility time in the forced swim test in mice.3 It also decreases flinching, as well as paw biting and licking, in the second phase of the formalin test in rats.4 Formulations containing desipramine have been used in the treatment of depression.
1.Owens, M.J., Neal, W., Plott, S.J., et al.Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolitesJ. Pharmacol. Exp. Ther.283(3)1305-1322(1997) 2.Kobayashi, T., Washiyama, K., and Ikeda, K.Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugsNeuropsychopharmacology29(10)1841-1851(2004) 3.Koek, W., Sandoval, T.L., and Daws, L.C.Effects of the antidepressants desipramine and fluvoxamine on latency to immobility and duration of immobility in the forced swim test in adult male C57BL/6J miceBehav. Pharmacol.29(5)453-456(2018) 4.Swaynok, J., Esser, M.J., and Reid, A.R.Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the ratPain82(2)149-158(1999)
| Cas No. | 61361-34-0 | SDF | Download SDF |
| 别名 | 盐酸去郁敏D4 | ||
| Canonical SMILES | CNCCCN1C2=C([2H])C=C([2H])C=C2CCC3=CC([2H])=CC([2H])=C31.Cl | ||
| 分子式 | C18H18D4N2 • HCl | 分子量 | 306.9 |
| 溶解度 | Water: soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2584 mL | 16.292 mL | 32.5839 mL |
| 5 mM | 0.6517 mL | 3.2584 mL | 6.5168 mL |
| 10 mM | 0.3258 mL | 1.6292 mL | 3.2584 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。