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Didanosine-d2 Sale

(Synonyms: 去羟肌苷 d2) 目录号 : GC49022

An internal standard for the quantification of didanosine

Didanosine-d2 Chemical Structure

Cas No.:69655-05-6

规格 价格 库存 购买数量
500 µg
¥1,696.00
现货
1 mg
¥3,221.00
现货
5 mg
¥13,568.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Didanosine-d2 is intended for use as an internal standard for the quantification of didanosine by GC- or LC-MS. Didanosine is an antiviral nucleoside analog and an inhibitor of reverse transcriptase.1 It undergoes cellular amination and phosphorylation to its active triphosphate form, 2’,3’-dideoxyadenosine 5’-triphosphate . Didanosine inhibits human T cell leukemia virus type 1 (HTLV-1) reverse transcriptase activity (IC50 = 30 nM).2 It inhibits the replication of HIV-1 clinical isolates containing various mutations in the gene encoding reverse transcriptase, pol, in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 0.3-11.1 μM).3 Didanosine inhibits proliferation and differentiation of primary human skeletal muscle cells (IC50s = 1 and 0.1 mM, respectively), as well as decreases the activities of mitochondrial complex IV, also known as cytochrome c oxidase, and mitochondrial complex II, also known as succinate dehydrogenase, in the same cells when used at a concentration of 1 mM.4 In vivo, didanosine protects mice from HIV infection (EC50 = 13.7 mg/kg).5 Formulations containing didanosine have been used in the treatment of HIV-1 infections.

1.Perry, C.M., and Noble, S.Didanosine: An updated review of its use in HIV infectionDrugs58(6)1099-1135(1999) 2.Anantharaman, V., and Moen, L.K.Effects of nucleoside analogs on native and site-directed mutants of HTLV type 1 reverse transcriptaseBioorg. Chem.28(5)293-305(2000) 3.Eron, J.J., Chow, Y.-K., Caliendo, A.M., et al.pol Mutations conferring zidovudine and didanosine resistance with different effects in vitro yield multiply resistant human immunodeficiency virus type 1 isolates in vivoAntimicrob. Agents Chemother.37(7)1480-1487(1993) 4.Benbrik, E., Chariot, P., Bonavaud, S., et al.Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cellsJ. Neurol. Sci.149(1)19-25(1997) 5.Kaneshima, H., Shih, C.C., Namikawa, R., et al.Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouseProc. Natl. Acad. Sci. USA88(10)4523-4527(1991)

Chemical Properties

Cas No. 69655-05-6 SDF
别名 去羟肌苷 d2
Canonical SMILES OC[C@@H]1CC[C@H](N2C([2H])N=C3C2N=C([2H])NC3=O)O1
分子式 C10H12D2N4O3 分子量 240.3
溶解度 DMSO : 62.5 mg/mL (264.57 mM; Need ultrasonic) 储存条件 -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 4.1615 mL 20.8073 mL 41.6146 mL
5 mM 0.8323 mL 4.1615 mL 8.3229 mL
10 mM 0.4161 mL 2.0807 mL 4.1615 mL
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