Diethyltoluamide (DEET)
(Synonyms: 避蚊胺; DEET; N,N-Diethyl-m-toluamide) 目录号 : GC32234
DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.
Cas No.:134-62-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
DEET (N,N-Diethyl-meta-toluamide, diethyltoluamide) is a commen active ingredient insect repellent.
| Cas No. | 134-62-3 | SDF | |
| 别名 | 避蚊胺; DEET; N,N-Diethyl-m-toluamide | ||
| Canonical SMILES | O=C(N(CC)CC)C1=CC=CC(C)=C1 | ||
| 分子式 | C12H17NO | 分子量 | 191.27 |
| 溶解度 | DMSO : ≥ 100 mg/mL (522.82 mM);Water : 2 mg/mL (10.46 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.2282 mL | 26.1411 mL | 52.2821 mL |
| 5 mM | 1.0456 mL | 5.2282 mL | 10.4564 mL |
| 10 mM | 0.5228 mL | 2.6141 mL | 5.2282 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Diethyltoluamide (DEET) insect repellent toxicosis
Vet Clin North Am Small Anim Pract 1990 Mar;20(2):387-91.PMID:2180185DOI:10.1016/s0195-5616(90)50033-9.
Poisonings resulting from DEET are rarely encountered in companion animals. In human patients, DEET toxicosis has been associated with the development of a toxic encephalopathy characterized by tremors, seizures, behavioral changes, and abnormal movements. Generally, DEET toxicosis in companion animals is of short duration and is characterized by vomiting, tremors, ataxia, and excitation. Treatment for DEET toxicosis includes symptomatic therapy and decontamination.
Is DEET a dangerous neurotoxicant?
Pest Manag Sci 2019 Aug;75(8):2068-2070.PMID:31069958DOI:10.1002/ps.5476.
Controversies surrounding the safety of N,N-diethyl-meta-toluamide (DEET) when used as an insect repellent are centered around conflicting findings in the scientific literature and inaccurate reporting in the public media. Lethal cases of DEET poisoning are few, and usually due to deliberate or other overdoses that ignore product label instructions. Deleterious effects of DEET typically involve skin reactions and even when encephalopathies, such as seizures, occur they often abate without sequelae. Recent mode-of-action studies prove it has little direct effect on acetylcholinesterase, and have identified G protein-coupled receptors as a site of action deserving of further investigation. Studies with pregnant women found that DEET had no effect on the developing fetus from proper use and its continued deployment as a repellent is endorsed by both the Centers for Disease Control and Prevention and the Environmental Protection Agency, with specific recommendations of how it should be used on children. 漏 2019 Society of Chemical Industry.
The mysterious multi-modal repellency of DEET
Fly (Austin) 2015;9(1):45-51.PMID:26252744DOI:10.1080/19336934.2015.1079360.
DEET is the most effective insect repellent available and has been widely used for more than half a century. Here, I review what is known about the olfactory and contact mechanisms of DEET repellency. For mosquitoes, DEET has at least two molecular targets: Odorant Receptors (ORs) mediate the effect of DEET at a distance, while unknown chemoreceptors mediate repellency upon contact. Additionally, the ionotropic receptor Ir40a has recently been identified as a putative DEET chemosensor in Drosophila. The mechanism of how DEET manipulates these molecular targets to induce insect avoidance in the vapor phase is also contested. Two hypotheses are the most likely: DEET activates an innate olfactory neural circuit leading to avoidance of hosts (smell and avoid hypothesis) or DEET has no behavioral effect on its own, but instead acts cooperatively with host odors to drive repellency (confusant hypothesis). Resolving this mystery will inform the search for a new generation of insect repellents.
DEET (N,N-diethyltoluamide) does not affect sperm number, viability and head morphology in male rats treated dermally
Drug Chem Toxicol 1983;6(4):379-95.PMID:6617532DOI:10.3109/01480548309082717.
DEET (N,N-Diethyltoluamide) was applied dermally to groups of 80 Sprague Dawley rats 5 days/week for 9 weeks (63 days), at three dose levels, (100, 300, and 1000 mg/kg). The undiluted material was applied with micropipettes to shaved patches. There was no run off and the material wet out onto the skin. Dose levels were calculated based on mean weights and adjusted weekly by reweighing half the animals in each group and calculating a mean body weight. Animals were scheduled for kill at three times; days 36-37, 65-66 and 95-96 after initiation of treatment. Data collected at each kill included sperm count, viability as assessed by ATP levels and morphology; testes histopathology (control and high-dose groups only) and body and organ weights (liver, kidneys and testes). DEET, when applied dermally, did not alter sperm count, sperm morphology, sperm viability, body weight or food consumption at any dose level tested.
Analysis of Diethyltoluamide (DEET) following intentional oral ingestion of Muscol
J Anal Toxicol 1995 May-Jun;19(3):197-9.PMID:7564300DOI:10.1093/jat/19.3.197.
N,N-Diethyl-m-toluamide (DEET) is an effective component of several insect repellent products. A 19-year-old woman was admitted to the emergency department following ingestion of 15-25 mL 95% diethyltoluamide (Muscol). Serum and urine toxicology screening tests were negative except for detection of DEET. DEET was qualitatively identified and quantitated by gas chromatography-mass spectrometry. Concentrations of DEET based on selected ion monitoring (ion at m/z 119) were 63.0, 17.2, 1.9, and less than 0.2 mg/L in serum specimens collected at 2, 5, 24, and 48 h following ingestion, respectively. Serial monitoring of DEET concentrations and the cardiac abnormalities observed in this case following oral ingestion were not reported previously.