Difloxacin HCl
(Synonyms: 盐酸二氟沙星) 目录号 : GC16213
A fluoroquinolone antibiotic
Cas No.:91296-86-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Difloxacin HCl is a quinolone antimicrobial antibiotic [1].
Quinolone antibiotics target bacterial DNA gyrase which is required during DNA replication, subsequent DNA synthesis and ultimately cell division.
In unselected cultured human neuroblastoma cells, difloxacin (50 microg/ml) increased sensitivity to the multidrug resistance-associated protein (MRP) substrates. Daunorubicin, doxorubicin, vincristine and potassium antimony tartrate is proportional to the level of MRP expression, which proves that difloxacin HCl reverse drug resistance in human neuroblastoma cells [1].
Difloxacin HCl is a quinolone antimicrobial antibiotic and may reverse drug resistance in human neuroblastoma cells. Difloxacin HCl is commonly used in clinical in vitro antimicrobial susceptibility tests against gram-positive and gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.
References:
[1]. Norris MD, Madafiglio J, Gilbert J, et al. Reversal of multidrug resistance-associated protein-mediated drug resistance in cultured human neuroblastoma cells by the quinolone antibiotic difloxacin. Med Pediatr Oncol, 2001, 36(1): 177-180.
| Cas No. | 91296-86-5 | SDF | |
| 别名 | 盐酸二氟沙星 | ||
| 化学名 | 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid | ||
| Canonical SMILES | CN1CCN(CC1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F | ||
| 分子式 | C21H19F2N3O3 HCl | 分子量 | 435.86 |
| 溶解度 | ≥ 9.15mg/mL in DMSO with gentle warming | 储存条件 | Store at 0-6°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.2943 mL | 11.4716 mL | 22.9431 mL |
| 5 mM | 0.4589 mL | 2.2943 mL | 4.5886 mL |
| 10 mM | 0.2294 mL | 1.1472 mL | 2.2943 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。