Dihydromethysticin ((+)-Dihydromethysticin)
(Synonyms: 二氢麻醉椒素,(+)-Dihydromethysticin) 目录号 : GC30479
A kavalactone with diverse biological activities
Cas No.:19902-91-1
Sample solution is provided at 25 µL, 10mM.
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Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties.1,2 Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM.3 Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice.1 It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.2
1.Jamieson, D.D., and Duffield, P.H.The antinociceptive actions of kava components in miceClin. Exp. Pharmacol. Physiol.17(7)495-507(1990) 2.Backhauβ, C., and Krieglstein, J.Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodentEur. J. Pharmacol.215(2-3)265-269(1992) 3.Weiss, J., Sauer, A., Frank, A., et al.Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitroDrug Metab. Dispos.33(11)1580-1583(2005)
| Cas No. | 19902-91-1 | SDF | |
| 别名 | 二氢麻醉椒素,(+)-Dihydromethysticin | ||
| Canonical SMILES | O=C1C=C(OC)C[C@H](CCC2=CC=C(OCO3)C3=C2)O1 | ||
| 分子式 | C15H16O5 | 分子量 | 276.28 |
| 溶解度 | DMSO : 100 mg/mL (361.95 mM; Need ultrasonic) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.6195 mL | 18.0976 mL | 36.1952 mL |
| 5 mM | 0.7239 mL | 3.6195 mL | 7.239 mL |
| 10 mM | 0.362 mL | 1.8098 mL | 3.6195 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet