Dihydrophytol
(Synonyms: 3,7,11,15-四甲基十六烷醇) 目录号 : GC47229
An intermediate in the biosynthesis of phytanic acid
Cas No.:645-72-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Dihydrophytol is an intermediate in the biosynthesis of phytanic acid .1 It is produced from phytol in the rumen of cattle.2
1.van den Brink, D.M., and Wanders, R.J.A.Phytanic acid: Production from phytol, its breakdown and role in human diseaseCell Mol. Life Sci.63(15)1752-1765(2006) 2.Patton, S., and Benson, A.A.Phytol metabolism in the bovineBiochim. Biophys. Acta125(1)22-32(1966)
| Cas No. | 645-72-7 | SDF | |
| 别名 | 3,7,11,15-四甲基十六烷醇 | ||
| Canonical SMILES | CC(CCCC(C)C)CCCC(C)CCCC(C)CCO | ||
| 分子式 | C20H42O | 分子量 | 298.6 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 10 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.349 mL | 16.7448 mL | 33.4896 mL |
| 5 mM | 0.6698 mL | 3.349 mL | 6.6979 mL |
| 10 mM | 0.3349 mL | 1.6745 mL | 3.349 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Metabolism of long-chain isoprenoid alcohols. Incorporation of phytol and Dihydrophytol into the lipids of rat brain
Biochim Biophys Acta 1975 Jan 24;380(1):119-26.PMID:1122306DOI:10.1016/0005-2760(75)90050-8.
[U-14-C]Phytol (3,7,11,15-tetramethylhexadec-2-en-1-ol) and [U-14-C]Dihydrophytol (3,7,11,15-tetramethylhexadecanol) were administered intracerebrally to 18-day-old rats and incorporation of radioactivity into brain lipids was determined after 6 and 24 h. Radioactivity from [U-14-C]phytol was found in free phytenic (3,7,11,15-tetramethylhexadec-2-enoic), phytanic (3,7,11,15-tetramethylhexadecanoic) and pristanic (2,6,10,14-tetramethylpentadecanoic) acids, in phytanic and pristanic acid moieties of neutral and polar lipids, and in esters of phytol. In addition, evidence is presented for the utilization of phytol to form 1-O-phytenyl-2-acyl glycerophosphatides. Radioactivity from [U-14-C]Dihydrophytol was found in free phytanic and pristanic acids, the corresponding acyl groups of neutral and polar lipids, esters of Dihydrophytol and 1-O-phytanyl-2-acyl glycerophosphatides. Incorporation of either substrate into O-alkylglycerols was very low, and labeled branched-chain alk-1-enylglycerols could not be detected.
Copepod fecal pellets as a source of Dihydrophytol in marine sediments
Science 1984 Jun 15;224(4654):1235-7.PMID:17819494DOI:10.1126/science.224.4654.1235.
Dihydrophytol(3,7,11,15-tetramethylhexadecanol) was identified in the nonsaponified lipid fraction of fecal pellets from the copepod Calanus helgolandicus fed in the laboratory on a unialgal diet. Direct deposition in the fecal pellets of certain zooplankton species may explain the presence of Dihydrophytol in marine sediments. Microbial reduction of phytol in sediment cores does not account for the origin of this compound in all sedimentary environments.
The occurrence of dihydrophytyl wax esters in bovine rumen liquor
Biochim Biophys Acta 1975 Jan 24;380(1):45-51.PMID:1122310DOI:10.1016/0005-2760(75)90043-0.
The purpose of this study was to examine the bovine rumen liquor wax esters and compare them with those of the dietary white clover leaf and stem tissues (Body, D.R. (1974) Phytochemistry 13, 1527-1530). The major fatty acid composition of the total bovine rumen liquor wax esters was made up of saturated fatty acids (62.1%) including palmitic (20.4%), stearic (16.2%) and other acids over the n-C19-n-C30 range (20.5%). However, 13.2% phytanic acid was also present. Of the two major fatty alcohol components, Dihydrophytol (33.4%) and triacontanol (20.2%) were the principal contributors. Approximately 30% of the total intact rumen liquor wax esters was a series of dihydrophytyl wax esters. These represented 0.6% of the total rumen liquor lipid extract. Individually they were comprised of dihydrophytyl palmitate (0.05%), dihydrophytyl phytanate (0.10%) and dihydrophytyl n-C18 fatty acids (0.45%). The appearance of saturated isoprenoid moieties was the most striking difference between the composition of rumen liquor and dietary white clover wax esters.
Fatty alcohols (normal and isoprenoid) in sediments
Science 1969 May 30;164(3883):1052-4.PMID:5769760DOI:10.1126/science.164.3883.1052.
Normal long-chain alcohols were isolated from Recent marine sediments from several environments. The isoprenoid alcohol Dihydrophytol, which is thought to originate from phytol, the side chain of chlorophyll, by hydrogenation in the reducing environment of the sediment, was also present in most of the samples. Both the normal and isoprenoid alcohols were found in the Green River shale (Eocene). Geochemical implications are considered.
Identification of feeding stimulants for boll weevils from cotton buds and anthers
J Chem Ecol 1985 Sep;11(9):1229-38.PMID:24310385DOI:10.1007/BF01024111.
Column chromatography of the pentane extract of freeze-dried cotton buds or anthers yielded a wax-sterol ester fraction that exhibited potent feeding stimulant activity for the cotton boll weevil. The waxes of the wax-sterol ester mixture were responsible for the feeding activity. Saponification of the wax-sterol ester fraction yielded about 15% alcohols and 85% sterols. A C18∶1 alcohol, Dihydrophytol, phytol, and geranylgeraniol constituted 15, 36, 26, and 23%, respectively, of the total alcohols, implicating certain of their long-chain esters as feeding stimulants. Several esters of Dihydrophytol, phytol, and geranylgeraniol were identified among the waxes by GC-MS. Certain phytol, geranylgeraniol, and oleyl alcohol esters containing C12 to C26 acid moieties were synthesized and were found to induce high feeding stimulant activity in the cotton boll weevil.