Diphenidol-d10
目录号 : GC49129
An internal standard for the quantification of diphenidol
Cas No.:2928181-97-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Diphenidol-d10 is intended for use as an internal standard for the quantification of diphenidol by GC- or LC-MS. Diphenidol is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.43, 2.8, 1.1, 0.91, and 1.28 µM in CHO cell membranes expressing M1-5 receptors, respectively).1 It also inhibits Kv channels in Neuro2A cells (IC50 = 28.2 µM), as well as L-type voltage-gated calcium channels in differentiated NG 108-15 cells in a concentration-dependent manner.2 Microiontophoretic application of diphenidol inhibits rotation-induced firing of medial vestibular nucleus neurons in a cat model of vertigo.3 Diphenidol (3.2 mg/kg, i.v.) prevents apomorphine-induced emesis in dogs.4 Formulations containing diphenidol have been used in the treatment of vertigo and as antiemetics.
1.Varoli, L., Andreani, A., Burnelli, S., et al.Diphenidol-related diamines as novel muscarinic M4 receptor antagonistsBioorg. Med. Chem. Lett.18(9)2972-2976(2008) 2.Leung, Y.M., Wong, K.L., Cheng, K.S., et al.Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidolPharmacol. Rep.64(3)739-744(2012) 3.Kawabata, A., Sasa, M., Kishimoto, T., et al.Effects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotationJpn. J. Pharmacol.55(1)101-106(1991) 4.Nakayama, H., Yamakuni, H., Nakayama, A., et al.Diphenidol has no actual broad antiemetic activity in dogs and ferretsJ. Pharmacol. Sci.96(3)301-306(2004)
| Cas No. | 2928181-97-7 | SDF | |
| Canonical SMILES | OC(C1=CC=CC=C1)(CCCN2C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C2([2H])[2H])C3=CC=CC=C3 | ||
| 分子式 | C21H17D10NO | 分子量 | 319.5 |
| 溶解度 | DMSO: soluble,Methanol: soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1299 mL | 15.6495 mL | 31.2989 mL |
| 5 mM | 0.626 mL | 3.1299 mL | 6.2598 mL |
| 10 mM | 0.313 mL | 1.5649 mL | 3.1299 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。