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DL-Alanine-2-d1 Sale

目录号 : GC66500

DL-Alanine-2-d1 是 DL-Alanine-2 氘代物.

DL-Alanine-2-d1 Chemical Structure

Cas No.:31024-91-6

规格 价格 库存 购买数量
100mg
¥1,195.00
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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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产品描述

DL-Alanine-2-d1 is the deuterium labeled DL-Alanine-2[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical Properties

Cas No. 31024-91-6 SDF Download SDF
分子式 C3H6DNO2 分子量 90.1
溶解度 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 11.0988 mL 55.4939 mL 110.9878 mL
5 mM 2.2198 mL 11.0988 mL 22.1976 mL
10 mM 1.1099 mL 5.5494 mL 11.0988 mL
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第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
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Research Update

E.s.r. of spin-trapped radicals in aqueous solutions of deuterated amino acids and alcohols

Int J Radiat Biol Relat Stud Phys Chem Med 1980 Oct;38(4):395-415.PMID:6254899DOI:10.1080/09553008014551771

Selectively deuterated compounds can be utilized in spin-trapping to obtain conclusive evidence for the structures of the trapped radicals. Radicals formed from DL-Alanine-2-d1, DL-alanine-3, 3, 3-d3, DL-alanine-d4, glycine-d5, isopropyl-2-d1 alcohol, isopropyl-d7 alcohol and t-butyl-d9 alcohol were studied. The hydrogen abstraction, deamination and decarboxylation radicals generated from deuterated alanines were investigated by spin-trapping using t-nitrosobutane. Since nitroxides of the type XYZC-CH2-N(O)-tBu which contain an asymmetric centre next to the CH2 group exhibit unequal beta-proton splittings and temperature-dependent line width alternations, the effects of temperature on the e.s.r. spectra were studied. By these methods the structures of the trapped radicals were verified and the hyperfine coupling constants could be assigned without ambiguity. In gamma-irradiated polycrystalline amino acids, the observed deuterium exchange can be conveniently surveyed by dissolution in aqueous solutions containing t-nitrosobutane.