DL-erythro-PDMP (hydrochloride)
目录号 : GC49672
A mixture of PDMP isomers
Cas No.:80943-40-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
DL-erythro-PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-erythro-(1S,2R)-PDMP and L-erythro-(1R,2S)-PDMP.1,2 It protects glucosylceramide (GlcCer) synthase from degradation and increases the level of ceramide in MDCK cells when used at a concentration of 40 µM.2 Unlike DL-threo-PDMP, DL-erythro-PDMP does not inhibit GlcCer synthase, but it does inhibit UDP galactose:ceramide galactosyltransferase by 27% in mouse brain microsomes when used at a concentration of 100 µM.3 It inhibits the growth of isolated rabbit skin fibroblasts when used at a concentration of 50 µM but is cytotoxic at concentrations higher than 50 µM.4 [Matreya, LLC. Catalog No. 1755]
1.Vunnam, R.R., and Radin, N.S.Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brainChem. Phys. Lipids26(3)265-278(1980) 2.Abe, A., Radin, N.S., and Shayman, J.A.Induction of glucosylceramide synthase by synthase inhibitors and ceramideBiochim. Biophys. Acta.1299(3)333-341(1996) 3.Inokuchi, J.i., and Radin, N.S.Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetaseJ. Lipid Res.28(5)565-571(1987) 4.Uemura, K., Sugiyama, E., Tamai, C., et al.Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblastsJ. Biochem.108(4)525-530(1990)
| Cas No. | 80943-40-4 | SDF | Download SDF |
| Canonical SMILES | CCCCCCCCCC(N[C@@H]([C@@H](O)C1=CC=CC=C1)CN2CCOCC2)=O.Cl | ||
| 分子式 | C23H38N2O3 • HCl | 分子量 | 427 |
| 溶解度 | DMF: 25 mg/mL,DMSO: 30 mg/mL,Ethanol: 50 mg/mL,Ethanol:PBS(pH 7.2) (1:5): 0.05 mg/mL | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3419 mL | 11.7096 mL | 23.4192 mL |
| 5 mM | 0.4684 mL | 2.3419 mL | 4.6838 mL |
| 10 mM | 0.2342 mL | 1.171 mL | 2.3419 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。