DL-Methionine methylsulfonium chloride
(Synonyms: DL-蛋氨酸甲基氯化锍) 目录号 : GC39671
Vitamin U (Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract.
Cas No.:3493-12-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Vitamin U (Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract.
Vitamin U inhibits adipocyte differentiation via down-regulation of adipogenic factors and up-regulation of AMPK activity[1]. Vitamin U, also known as S-methyl methionine is found to increase activity of S-adenosyl-L-homocysteine. This decreases the inhibition of S-adenosyl-L-homocystein and stimulates methylation process[2].
"vitamin U" is recommended for treating oesophagogastric lesions, chronic gastric ulceration, chronic gastritis, ulcerative colitis, diaphragmatic hernias and peptic ulcers. "Vitamin U" is also recommended as a preventive vitamin for the digestive and intestinal systems. It is found that vitamin U can be used as a donor of methyl groups during bacterial DNA methylation in vivo without changing the specificity of DNA methylation. Vitamin U dose-dependently lowers the increased plasma LDL and normalizes the decreased HDL in dietary-induced hyperlipidemic rats[2].
[1] Lee NY, et al. Ann Dermatol. 2012, 24(1):39-44. [2] Asha D Patel, et al. Journal of Chemical and Pharmaceutical Research, 2012, 4(1):209-215.
| Cas No. | 3493-12-7 | SDF | |
| 别名 | DL-蛋氨酸甲基氯化锍 | ||
| Canonical SMILES | C[S+](CCC(N)C(O)=O)C.[Cl-] | ||
| 分子式 | C6H14ClNO2S | 分子量 | 199.7 |
| 溶解度 | Water: 250 mg/mL (1251.88 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.0075 mL | 25.0376 mL | 50.0751 mL |
| 5 mM | 1.0015 mL | 5.0075 mL | 10.015 mL |
| 10 mM | 0.5008 mL | 2.5038 mL | 5.0075 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Role of sulfhydryl-containing agents in the healing of erosive gastritis and chronic gastric ulceration in the rat
J Pharm Sci 1992 Jan;81(1):70-3.PMID:1619573DOI:10.1002/jps.2600810114.
One milliliter of 1, 2, or 5% DL-cysteine (cysteine) or DL-Methionine methylsulfonium chloride (MMSC) was instilled into the rat stomach 1, 24, and 48 h after giving ethanol (1 mL of 40% solution) by gavage. One hour following the administration of ethanol, gastric mucosal injury was seen in all the animals (22.6 +/- 1.1 mm2, mean +/- SEM; n = 10). Twenty-four hours after giving the ethanol, all the rats treated with cysteine or MMSC still had the mucosal injury. Treatment with 2% cysteine or MMSC significantly (p less than 0.01) reduced the extent of this injury (10.2 +/- 0.6 and 10.1 +/- 0.5 mm2, respectively, versus 20.7 +/- 1.2 mm2, mean +/- SEM; n = 10), an action that was similarly achieved by the 5% solutions (10.1 +/- 0.5 and 9.9 +/- 0.3 mm2, respectively, versus 20.7 +/- 1.2 mm2, mean +/- SEM; n = 10). Forty-eight hours following the administration of ethanol, 30% of the animals given 1% cysteine or MMSC still had gastric mucosal injury, which was significantly (p less than 0.001) less extensive than that seen with ethanol alone (3.8 +/- 0.3 and 4.1 +/- 0.3 mm2, respectively, versus 13.1 +/- 0.8 mm2, mean +/- SEM; n = 10). At this time period, however, none of the animals treated with 2 or 5% solutions of cysteine or MMSC still had any injury. Healing of the ethanol-induced injury was confirmed microscopically and was achieved by regeneration.(ABSTRACT TRUNCATED AT 250 WORDS)