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DLPC Sale

(Synonyms: 1,2-二十二酰基-SN-GLYCERO-3-胆碱磷酸,DLPC) 目录号 : GC14047

A phospholipid

DLPC Chemical Structure

Cas No.:18194-25-7

规格 价格 库存 购买数量
10mM (in 1mL EtOH)
¥347.00
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50mg
¥420.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

IC50: N/A

DLPC is an LRH-1 agonist ligand.

The orphan nuclear receptor liver receptor homolog-1 (LRH-1) is recognized as a critical regulator of bile salt biosynthesis. Bile salts are recognized increasingly as modulators of glucose and lipid metabolism in both human and animals.

In vitro: In a cell-free system, DLPC specifically bound to a recombinant LRH-1 ligand-binding domain. At functional level, DLPC was found to be a strong activator of both human and mouse LRH-1, while other nuclear receptors including FXR, CAR, PXR, PPARa and PPARc were all unaffected by DLPC in cell culture. In addition, DLPC induced the transactivation of the native mouse Shp and Oct4 promoters, consistent with previous studies on Lrh-1. In HepG2 cell line, DLPC could induce the expression of CYP8B1 [1].

In vivo: In mouse in vivo test, DLPC induced bile acid biosynthetic enzymes in mouse liver, lowered hepatic triglycerides and serum glucose, and increased bile acid levels. Moreover, DLPC treatment was also able to decrease hepatic steatosis and improve glucose homeostasis in two mouse models of insulin resistance [1].

Clinical trial: In a previous clinical study, single-dose inhalations of liposome preparations of Bec-DLPC and DLPC alone were administered. Results showed that no adverse clinical or laboratory events were observed. Thus, it was concluded that DLPC liposome aerosol was well tolerated in doses equivalent to those administered by MDIs for treatment of asthma [2].

References:
[1] Hohenester S,Beuers U.  Phosphatidylcholines as regulators of glucose and lipid homeostasis: promises and potential risks. Hepatology.2011 Dec;54(6):2265-7.
[2] Waldrep JC,Gilbert BE,Knight CM,Black MB,Scherer PW,Knight V,Eschenbacher W. Pulmonary delivery of beclomethasone liposome aerosol in volunteers. Tolerance and safety. Chest.1997 Feb;111(2):316-23.

Chemical Properties

Cas No. 18194-25-7 SDF
别名 1,2-二十二酰基-SN-GLYCERO-3-胆碱磷酸,DLPC
化学名 (R)-2,3-bis(dodecanoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
Canonical SMILES O=C(CCCCCCCCCCC)O[C@@H](CO[P@](OCC[N+](C)(C)C)([O-])=O)COC(CCCCCCCCCCC)=O
分子式 C32H64NO8P 分子量 621.83
溶解度 100 mg/mL in Ethanol 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.6082 mL 8.0408 mL 16.0816 mL
5 mM 0.3216 mL 1.6082 mL 3.2163 mL
10 mM 0.1608 mL 0.8041 mL 1.6082 mL
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