DNALI1 Human
目录号 : GP23330Dynein Axonemal Light Intermediate Chain 1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greaterthan 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Dynein; Axonemal; Light Intermediate Chain 1; DJ423B22.5(Axonemal Dynein Light Chain (Hp28)); Inner Dynein Arm Light Chain Axonemal;hp28; P28; Homolog Of Clamydomonas; Axonemal Dynein Light IntermediatePolypeptide 1; dJ423B22.5; Inner Dynein Arm;Homolog Of Clamydomonas; Dynein; Axonemal; Light Intermediate Polypeptide 1. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMVTANKA HTGQGSCWVA TLASAMIPPA DSLLKYDTPV LVSRNTEKRSPKARLLKVSP QQPGPSGSAP QPPKTKLPST PCVPDPTKQA EEILNAILPP REWVEDTQLW IQQVSSTPSTRMDVVHLQEQ LDLKLQQRQA RETGICPVRR ELYSQCFDEL IREVTINCAE RGLLLLRVRDEIRMTIAAYQ TLYESSVAFG MRKALQAEQG KSDMERKIAE LETEKRDLER QVNEQKAKCE ATEKRESERRQVEEKKHNEE IQFLKRTNQQ LKAQLEGIIA PKK | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. | ||
| Formulation | DNALI1 protein solution (1mg/ml)containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol, 1mM DTT and0.1mM PMSF. | ||
DyneinAxonemal Light Intermediate Chain 1 also known as DNALI1 belongs to theinner dynein arm light chain family. DNALI1 take a dynamic role in flagellarmotility. DNALI1 is the human homolog of the Chlamydomonas inner dynein armgene, p28. The exact function of DNALI1 is not knownyet, on the other hand, it is a potential candidate for immotile ciliasyndrome. In addition it has been found that the following diseases: primaryciliary dyskinesia, and huntington's disease have been associated with DNALI1. Ultrastructuraldefects of the inner dynein arms are seen in patients with ICS. Immotile mutantstrains of Chlamydomonas, biflagellated algae,show similar defects.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.