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Docetaxel-d9 Sale

(Synonyms: 多烯紫杉醇D9,RP-56976-d9) 目录号 : GC47250

An internal standard for the quantification of docetaxel

Docetaxel-d9 Chemical Structure

Cas No.:940867-25-4

规格 价格 库存 购买数量
500 μg
¥3,543.00
现货
1 mg
¥6,730.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Docetaxel-d9 is intended for use as an internal standard for the quantification of docetaxel by GC- or LC-MS. Docetaxel is a semisynthetic analog of paclitaxel that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM).1 It has proven more effective than taxol in preventing the proliferation of cancer cells.1,2 Docetaxel has potential applications in breast cancer and hormone-refractory prostate cancer.3,4

1.Bissery, M.C., Guenard, D., Gueritte-Voegelein, F., et al.Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogueCancer Research514845-4852(1991) 2.Pazdur, R., Kudelka, A.P., Kavanagh, J.J., et al.The taxoids: Paclitaxel (Taxolr) and docetaxel (Taxoterer)Cancer Treatment Reviews19351-386(1993) 3.Mahon, K.L., Henshall, S.M., Sutherland, R.L., et al.Pathways of chemotherapy resistance in castration-resistant prostate cancerEndocrine-Related Cancer18R103-R123(2011) 4.Yao, X., Hosenpud, J., Chitambar, C.R., et al.A phase II study of concurrent docetaxel, epirubicin and cyclophospha-mide as a neoadjuvant chemotherapy regimen in patients with locally advanced breast cancerJournal of Cancer3145-151(2012)

Chemical Properties

Cas No. 940867-25-4 SDF
别名 多烯紫杉醇D9,RP-56976-d9
Canonical SMILES CC(C1=C(C)[C@@H](OC([C@H](O)[C@@H](NC(OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C2=CC=CC=C2)=O)C3)(C)[C@]3(O)[C@@H](OC(C4=CC=CC=C4)=O)[C@@]([C@@](CO5)(OC(C)=O)[C@@]5([H])C[C@@H]6O)([H])[C@]6(C)C([C@@H]1O)=O
分子式 C43H44D9NO14 分子量 816.9
溶解度 Chloroform: Slightly Soluble,Methanol: Slightly Soluble 储存条件 Store at -20°C
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1 mM 1.2241 mL 6.1207 mL 12.2414 mL
5 mM 0.2448 mL 1.2241 mL 2.4483 mL
10 mM 0.1224 mL 0.6121 mL 1.2241 mL
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Research Update

Quantification of Docetaxel in Serum Using Turbulent Flow Liquid Chromatography Electrospray Tandem Mass Spectrometry (TFC-HPLC-ESI-MS/MS)

Methods Mol Biol 2016;1383:121-4.PMID:26660181DOI:10.1007/978-1-4939-3252-8_14

Docetaxel is a second-generation taxane and is used clinically as an anti-neoplastic agent in cancer chemotherapy via an anti-mitotic mechanism. Its efficacy is limited to a narrow therapeutic window. Inappropriately high concentrations may cause erythema, fluid retention, nausea, diarrhea, and neutropenia. As a result, dosing recommendations have changed from high dosage loading every 3 weeks to lower dosage loading weekly. We describe a method that can be used for therapeutic drug monitoring of docetaxel levels using turbulent flow liquid chromatography electrospray tandem mass spectrometry (TFC-HPLC-ESI-MS/MS). The method is rapid, requiring only 6.3 min per analytical run following a simple protein crash. The method requires only 100 μL of serum. Concentrations of docetaxel were quantified by a calibration curve relating the peak-area ratio of docetaxel to a deuterated internal standard (Docetaxel-d9). The method was linear from 7.8 to 1000 ng/mL, with imprecision ≤6.2 %.