Docosanoic Acid-d43
(Synonyms: 氘代二十二烷酸(D43)) 目录号 : GC45881
An internal standard for the quantification of docosanoic acid
Cas No.:29823-26-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Docosanoic acid-d43 is intended for use as an internal standard for the quantification of docosanoic acid by GC- or LC-MS. Docosanoic acid is a long-chain saturated fatty acid. It has been found in peanut and M. oleifera seed oils.1,2 It inhibits the double-stranded DNA binding activity of p53 through a direct interaction with the DNA binding domain (Kd = 12 nM).3 Docosanoic acid inhibits rat DNA polymerase β and human DNA polymerase Λ activity in cell-free enzyme assays when used at a concentration of 100 μM and inhibits human DNA topoisomerase I and II relaxation activity at a concentration of 25 μM.4 Liver levels of docosanoic acid are reduced in rats fed a high-fat or a high-fat and high-cholesterol diet but not a high-cholesterol only diet.5 Formulations containing docosanoic acid have been used in hair conditioner and moisturizers.
|1. Dean, L.L., and Sanders, T.H. Hexacosanoic acid and other very long-chain fatty acids in peanut seed oil. Plant Genet. Resour. 7(3), 252-256 (2009).|2. SÁnchez-Machado, D.I., LÓpez-Cervantes, J., NÚ•ez-GastÉlum, J.A., et al. Effect of the refining process on Moringa oleifera seed oil quality. Food Chem. 187, 53-57 (2015).|3. Iijima, H., Kasai, N., Chiku, H., et al. The inhibitory action of long-chain fatty acids on the DNA binding activity of p53. Lipids 41(6), 521-527 (2006).|4. Yonezawa, Y., Hada, T., Uryu, K., et al. Inhibitory action of C22-fatty acids on DNA polymerases and DNA topoisomerases. Int. J. Mol. Med. 18(4), 583-588 (2006).|5. Serviddio, G., Bellanti, F., Villani, R., et al. Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach. Redox Biol. 9, 296-305 (2016).
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6048 mL | 13.0242 mL | 26.0485 mL |
| 5 mM | 0.521 mL | 2.6048 mL | 5.2097 mL |
| 10 mM | 0.2605 mL | 1.3024 mL | 2.6048 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。