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DPPP Sale

(Synonyms: 二苯基-1-芘基膦,DPPP) 目录号 : GC43569

A fluorescent probe for detection of hydroperoxides

DPPP Chemical Structure

Cas No.:110231-30-6

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5mg
¥1,453.00
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10mg
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¥6,026.00
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50mg
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产品描述

DPPP is a probe that reacts stoichiometrically with hydroperoxides to yield the fluorescent molecule diphenyl-1-pyrenylphosphine oxide (DPPP-O). Plasma levels of lipid hydroperoxides of phosphatidylcholine, phosphatidylethanolamine, triglycerides, and cholesteryl esters have been measured by HPLC with a post column detection system using DPPP. DPPP has also been used as a fluorescent probe for the detection of low density lipoprotein and cellular oxidation. Fluorescence of DPPP-O can be monitor using excitation and emission wavelengths of 351 nm and 380 nm, respectively.

Chemical Properties

Cas No. 110231-30-6 SDF
别名 二苯基-1-芘基膦,DPPP
Canonical SMILES c1ccc(cc1)P(c1ccccc1)c1ccc2ccc3cccc4ccc1c2c34
分子式 C28H19P 分子量 386.4
溶解度 DMF: 10 mg/ml,Methylene Chloride: 1 mg/ml 储存条件 Store at -20°C,protect from light
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.588 mL 12.94 mL 25.8799 mL
5 mM 0.5176 mL 2.588 mL 5.176 mL
10 mM 0.2588 mL 1.294 mL 2.588 mL
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Research Update

Mechanistic Insights into Oxidation-Induced Size Conversion of [Au6(DPPP)4]2+ to [Au8(DPPP)4Cl2]2

Inorg Chem 2022 Dec 12;61(49):19773-19779.PMID:36423328DOI:10.1021/acs.inorgchem.2c02885.

Oxidation-induced conversion of gold nanoclusters is an important strategy for preparing novel atomically precise clusters and elucidating the kinetic correlations of different clusters. Herein, the oxidation-induced growth from [Au6(DPPP)4]2+ to [Au8(DPPP)4Cl2]2+ (reported by Konishi and co-workers) has been studied by density functional theory calculations. A successive oxidation → Cl- coordination → oxidation → Cl- coordination sequence occurs first to activate the Au6 structure, resulting in the high Au(core)-Au(corner) bond cleavage activity and the subsequent formation of [Au2(DPPP)2Cl]+ and [Au4(DPPP)2Cl]+ fragments. Then, the dimerization of two Au4 fragments and the rearrangement of the diphosphine coordination occur to generate the thermodynamically stable [Au8(DPPP)4Cl2]2+ products. The proposed mechanism agrees with the experimental outcome for the fast reaction rate and the residual of the Au2 components. Specifically, a multivariate linear regression analysis indicates the strong correlation of the oxidation potential of Au6, Au8, Au23, and Au25 clusters with the HOMO energy, the number of Au atoms, and cluster charge state. The main conclusions [e.g., oxidation-induced Au(corner)-Au(core) bond activation, easy 1,2-P transfer steps, etc.] of this study might be widely applicable in improving our understanding of the mechanism of other cluster-conversion reactions.

Comparing DPPP fluorescence and UV based methods to assess oxidation degree of krill oil-in-water emulsions

Food Chem 2021 Mar 1;339:127898.PMID:32871303DOI:10.1016/j.foodchem.2020.127898.

In this study, lipid oxidation evaluation methods were compared for a krill-oil-in-water emulsion system. With this aim, thiocyanate and DPPP (diphenyl-1-pyrenylphosphine) fluorescence methods were comparatively examined to determine primary oxidation products. 2-thiobarbituric acid reactive substances (TBARS), hexanal and propanal formation were also monitored as secondary oxidations products. All oxidation experiments were performed via both auto-oxidation at 45 °C and light-riboflavin induced photooxidation at 37 °C. The results have shown that thiocyanate method was not suitable to measure lipid hydroperoxides by the both in auto- and photo-oxidation systems. On the other hand, fluorescence intensity of samples containing the DPPP probe increased during incubation period which indicates the formation of lipid hydroperoxides could be detected via this method. TBARS, hexanal and propanal concentrations also increased during storage period and the formation kinetics of secondary oxidation products was confirmed that the DPPP fluorescence method was accurate and reliable at different environmental conditions.

Unravelling the Photochemical Transformations of Chromium(I) 1,3 Bis(diphenylphosphino), [Cr(CO)4(DPPP)]+, by EPR Spectroscopy

Organometallics 2019 Jun 24;38(12):2523-2529.PMID:32055085DOI:10.1021/acs.organomet.9b00226.

UV-induced photochemical transformations of the paramagnetic [Cr(CO)4(Ph2PCH2CH2CH2PPh2)]+ complex (abbreviated [Cr(CO)4(DPPP)]+) in dichloromethane was investigated by CW EPR spectroscopy. Room-temperature UV irradiation results in the rapid transformation of [Cr(CO)4(DPPP)]+ into trans-[Cr(CO)2(DPPP)2]+. However, low-temperature (77-120 K) UV irradiation reveals the presence of an intermediate mer-[Cr(CO)3(κ1-dppp)(κ2-dppp)]+ complex which photochemically transforms into trans-[Cr(CO)2(DPPP)2]+. The derived spin Hamiltonian parameters for these complexes were confirmed by DFT calculations. The photoinduced reaction is shown to be concentration-dependent, leading to a distribution of the three complexes ([Cr(CO)4(DPPP)]+, mer-[Cr(CO)3(κ1-dppp)(κ 2-dppp)]+, and trans-[Cr(CO)2(DPPP)2]+). A bimolecular photoinduced mechanism is proposed to account for the formation of mer-[Cr(CO)3(κ1-dppp)(κ2-dppp)]+ and trans-[Cr(CO)2(DPPP)2]+.

Mechanistic insights into Ag+ induced size-growth from [Au6(DPPP)4]2+ to [Au7(DPPP)4]2+ clusters

Nanoscale Adv 2022 Jul 4;4(18):3737-3744.PMID:36133347DOI:10.1039/d2na00301e.

The size conversion of atomically precise metal nanoclusters lays the foundation to elucidate the inherent structure-activity correlations on the nanometer scale. Herein, the mechanism of the Ag+-induced size growth from [Au6(DPPP)4]2+ to [Au7(DPPP)4]3+ (DPPP is short for 1,3-bis(diphenylphosphino)propane) is studied via density functional theory (DFT) calculations. In the absence of extra Au sources, the one "Au+" addition was found to be regulated by the Ag+ doping induced Au-activation, i.e., the formation of formal Au(i) blocks via the Ag+ alloying processes. The Au(i) blocks could be extruded from the core structure in the formed Au-Ag alloy clusters, triggering a facile Au+ migration to the Au6 precursor to form the Au7 product. This study sheds light on the structural and stability changes of gold nanoclusters upon the addition of Ag+ and will hopefully benefit the development of more metal ion-induced size-conversion of metal nanoclusters.

Host-Guest Feature of DPPP Bridged Arene-Ruthenium Clip Derived Molecular Rectangle

Inorg Chem 2019 Aug 19;58(16):10991-10999.PMID:31365239DOI:10.1021/acs.inorgchem.9b01468.

The development of DPPP2- (H2DPPP = 2,5-dihydro-3,6-di-2-pyridylpyrrolo(3,4-c)pyrrole-1,4-dione) bridged (NN∩NN) diruthenium complexes [(Cym)(X)RuII(μ-dppp)RuII(X)(Cym)] (Cym = para-cymene and X = OTf- (1), SCN- (2), N3- (3), NO2-(4)) are considered as the probable molecular clips for the construction of metallarectangle. Crystal structures of 2-4 established anticonfiguration with respect to monodentate SCN-, N3- and NO2- groups, respectively. Though molecular clips 2-4 failed to provide the desired metallarectangle in combination with the 4,4'-bipyridine spacer, 1 with the labile OTf groups facilitated to achieve the metallarectangle 5. The crystal structure of 5 revealed that two twisted 4,4'-bipyridine spacers bridged between the two units of dimeric 1 in symmetric fashion, which in effect led to the newer class of molecular rectangle 5 with a hydrophobic cavity size of the cationic host of 8.32 × 11.11 Å2. Furthermore, the host-guest interaction potential of 5 with special reference to the guest molecule, pyrene, was explored. The crystal structure of the resultant molecule 6 ascertained the partial encapsulation of two pyrene molecules inside the hydrophobic cavity of 5, due to the twisted 4,4'-bipyridine spacer units between the two ruthenium clips. It also attributed a noncovalent CH-π interaction involving protons of pyrene and the π-electron cloud of 4,4'-bipyridine as well as a weak interaction between pyrene protons and the pendant C═O group of DPPP. Encapsulation of the guest molecule (pyrene) inside the cavity of the metallarectangle was also monitored by following the quenching of florescent intensity of pyrene on addition of 5.