Dronedarone-d6 (hydrochloride)
(Synonyms: 决奈达隆 D6) 目录号 : GC47272
An internal standard for the quantification of dronedarone
Cas No.:1329809-23-5
Sample solution is provided at 25 µL, 10mM.
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Dronedarone-d6 is intended for use as an internal standard for the quantification of dronedarone by GC- or LC-MS. Dronedarone is an antiarrhythmic agent and a derivative of amiodarone .1,2 It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively).2 Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing.3 Formulations containing dronedarone have been used in the treatment of atrial fibrillation.
1.Sun, W., Sarma, J.S., and Singh, B.N.Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart: Comparison with amiodaroneCirculation100(22)2276-2281(1999) 2.Guillemare, E., Marion, A., Nisato, D., et al.Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cellsJ. Cardiovasc. Pharmacol.36(6)802-805(2000) 3.Saengklub, N., Limprasutr, V., Sawangkoon, S., et al.Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillationExp. Anim.66(3)251-258(2017)
| Cas No. | 1329809-23-5 | SDF | |
| 别名 | 决奈达隆 D6 | ||
| Canonical SMILES | CCCCC1=C(C(C2=CC=C(OC([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCCC)CCCC)C=C2)=O)C3=CC(NS(C)(=O)=O)=CC=C3O1.Cl | ||
| 分子式 | C31H38D6N2O5S.HCl | 分子量 | 599.3 |
| 溶解度 | Chloroform: Slightly soluble,Methanol: Slightly soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6686 mL | 8.3431 mL | 16.6861 mL |
| 5 mM | 0.3337 mL | 1.6686 mL | 3.3372 mL |
| 10 mM | 0.1669 mL | 0.8343 mL | 1.6686 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet