(E)-Methyl 4-coumarate

Methyl 4-hydroxycinnamate is a phenol and derivative of p-coumaric acid that has been found in Allium cepa and has diverse biological activities.^1,2,3,4 It scavenges DPPH radicals in a cell-free assay (IC₅₀ = 772.47 ?M).³ Methyl 4-hydroxycinnamate reduces LPS-induced nitric oxide (NO) production in RAW 264.7 cells (IC₅₀ = 19.29 ?M).⁴ It synergizes with curcumin to induce apoptosis in HL-60 acute myeloid leukemia cells when used at a concentration of 5 ?M.¹ Methyl 4-hydroxycinnamate (10, 30, and 60 mg/kg) reduces parasitemia and increases survival in P. berghei-infected mice.²

1.Trachtenberg, A., Muduli, S., Sidoryk, K., et al.Synergistic cytotoxicity of methyl 4-hydroxycinnamate and carnosic acid to acute myeloid leukemia cells via calcium-dependent apoptosis inductionFront. Pharmacol.10507(2019) 2.Sudi, S., Ali, A.H., Basir, R., et al.A derivative of cinnamic acid, methyl-4-hydroxycinnamate modules inflammatory cytokine levels in malaria-infected mice through inhibition of GSK3βMalays. Appl. Biol.47(3)153-157(2018) 3.Wan, C., Yuan, T., Cirello, A.L., et al.Antioxidant and α-glucosidase inhibitory phenolics isolated from highbush blueberry flowersFood Chem.135(3)1929-1937(2012) 4.Jung, Y.-J., Park, J.-H., Seo, K.-H., et al.Phenolic compounds from the stems of Zea mays and their pharmacological activityJ. Korean Soc. Appl. Biol. Chem.57(3)379-385(2014)