EDA2R Human
目录号 : GP23353Ectodysplasin A2 Receptor Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 90.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Ectodysplasin A2 Receptor; XEDAR; TNFRSF27; EDA-A2 Receptor; X-Linked Ectodysplasin-A2 Receptor; EDAA2R; EDA-A2R; Tumor Necrosis Factor Receptor Superfamily Member 27; Tumor Necrosis Factor Receptor Superfamily Member XEDAR; EDAR2. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPRRYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQCAFQLSLVEA DAPTVPPQEA T | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. | ||
| Formulation | EDA2R protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. | ||
EDA2R (ectodysplasin A2 receptor) mediates the activation of theNF-kappa-B and JNK pathways. Activation seems to be mediated through binding toTRAF3 and TRAF6. In addition, Mutations in EDA give rise to a clinical syndromecharacterized by loss of hair, sweat glands, and teeth. EDA2R specificallybinds to EDA-A2 isoform. This protein is a type III transmembrane protein ofthe TNFR (tumor necrosis factor receptor) superfamily, and contains 3cysteine-rich repeats and a single transmembrane domain however it lacks anN-terminal signal peptide. Alternatively spliced transcript variants have been foundfor this gene. Among the diseases associated with EDA2R are ectodermaldysplasia 1, hypohidrotic, x-linked, and hypohidrotic ectodermal dysplasia.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.