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EHNA hydrochloride

(Synonyms: 外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐) 目录号 : GC10935

A dual inhibitor of PDE2 and ADA

EHNA hydrochloride Chemical Structure

Cas No.:58337-38-5

规格 价格 库存 购买数量
5mg
¥460.00
现货
10mg
¥825.00
现货
25mg
¥1,919.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

EHNA is a reversible adenosine deaminase inhibitor (IC50 = 1.2 μM in human red blood cells) that also selectively inhibits the cGMP-specific phosphodiesterase (PDE2) (IC50s = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet).[1],[2] Comparatively, EHNA is much less potent at inhibiting PDE1, PDE3, or PDE4 (IC50s > 100 μM).1 EHNA has been used to evaluate cardioprotective and neuroprotective effects during ischemia, to study the role of cAMP/cGMP signaling, and to maintain pluripotency/prevent differentiation of human embryonic stem cells.[3],[4][5]

Reference
[1]. Podzuweit, T., Nennstiel, P., and Müller, A. Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine. Cell. Signal. 7(7), 733-738 (1995).[
[2]. Michie, A.M., Lobban, M., Müller, T., et al. Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell. Signal. 8(2), 97-110 (1996).
[3]. Barankiewicz, J., Danks, A.M., Abushanab, E., et al. Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors. J. Pharmacol. Exp. Ther. 283(3), 1230-1238 (1997).
[4]. Dickinson, N.T., Jang, E.K., and Haslam, R.J. Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: Effects on platelet aggregation. Biochem. J. 323(Pt. 2), 371-377 (1997).
[5]. Burton, P., Adams, D.R., Abraham, A., et al. Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochem. J. 432(3), 575-584 (2010).

Chemical Properties

Cas No. 58337-38-5 SDF
别名 外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐
化学名 (2R,3S)-3-(6-amino-9H-purin-9-yl)nonan-2-ol hydrochloride
Canonical SMILES O[C@H](C)[C@H](CCCCCC)N1C2=NC=NC(N)=C2N=C1.Cl
分子式 C14H23N5O.HCl 分子量 313.83
溶解度 30mg/mL in DMSO, 30mg/mL in DMF, 20mg/mL in Ethanol, 10mg/mL in Water 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 3.1864 mL 15.9322 mL 31.8644 mL
5 mM 0.6373 mL 3.1864 mL 6.3729 mL
10 mM 0.3186 mL 1.5932 mL 3.1864 mL
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